GJB3 and TUBD1

Data Source: HiPPIP (Novel)

		GJB3	TUBD1
Name		gap junction protein beta 3	tubulin delta 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Cell Projection
	Molecular Function	Gap Junction Channel Activity Protein Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Placenta Development Cell Communication Cell-cell Signaling Transmembrane Transport	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway
Pathways		Gap junction assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	None
Drugs		None	Vinblastine
Diseases		Deafness, autosomal recessive Erythrokeratodermia variabilis Deafness, autosomal dominant	None
GWAS		Intraocular pressure ( 30591961 ) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883 )	C-reactive protein levels ( 30388399 ) Chronotype ( 30696823 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 23128233 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 29403010 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Systolic blood pressure ( 30578418 )
Novel Interactors		1 novel interactors: TUBD1	6 novel interactors: EPX GJB3 PTRH2 RFX5 TMED1 TRPV1
Interacting Genes		15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1	1 interacting genes: TOP1
Entrez ID		2707	51174
HPRD ID		04505	06297
Ensembl ID		ENSG00000188910	ENSG00000108423
Uniprot IDs		O75712	Q9UJT1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Response To Purine-containing Compound DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component Response To Temperature Stimulus Detection Of Temperature Stimulus Involved In Thermoception Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Temperature-gated Ion Channel Activity Smooth Muscle Contraction Involved In Micturition Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Thermoception Response To Capsazepine Lactoperoxidase Activity Defense Response To Nematode Peptidyl-tRNA Hydrolase Activity