GJB3 and SERP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB3	SERP1
Description		gap junction protein beta 3	stress associated endoplasmic reticulum protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding
	Biological Process	Placenta Development Cell Communication Cell-cell Signaling Transmembrane Transport	Skeletal System Development Glucose Metabolic Process Protein Glycosylation Response To Unfolded Protein Plasma Membrane Organization Post-embryonic Development Protein Transport Insulin Secretion Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion
Pathways		Gap junction assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Deafness, autosomal recessive Erythrokeratodermia variabilis Deafness, autosomal dominant
GWAS		Intraocular pressure ( 30591961) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Academic attainment (English) ( 33594131)
Interacting Genes		15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1	56 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FKBP7 FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A1 SLC10A6 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SLC71A2 SSMEM1 STX1A STX2 STX4 TIMMDC1 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9
Entrez ID		2707	27230
HPRD ID		04505	18037
Ensembl ID		ENSG00000188910	ENSG00000120742
Uniprot IDs		O75712	Q9Y6X1
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane Transmembrane Transport Norepinephrine Uptake Endoplasmic Reticulum Serotonin Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Amine Transport Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Protein Binding Neurotransmitter Transport Apical Plasma Membrane Mitochondrial Membrane Endoplasmic Reticulum Membrane Putrescine Transmembrane Transporter Activity Monoatomic Ion Transport Neurotransmitter Reuptake Dopamine Transport Sensory Perception Of Salty Taste Xenobiotic Transmembrane Transporter Activity Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Bile Acid:sodium Symporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Neurotransmitter Uptake Lumenal Side Of Endoplasmic Reticulum Membrane Basolateral Plasma Membrane External Side Of Plasma Membrane Cornified Envelope Assembly Monoatomic Cation Transport Xenobiotic Transport Across Blood-brain Barrier Sec61 Translocon Complex Import Into Cell Organic Cation Transport Organic Hydroxy Compound Transport Cellular Response To Aldosterone Sodium Channel Complex Toxin Transmembrane Transporter Activity
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