GJB3 and BTN2A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB3	BTN2A2
Description		gap junction protein beta 3	butyrophilin subfamily 2 member A2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Placenta Development Cell Communication Cell-cell Signaling Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Gap junction assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Butyrophilin (BTN) family interactions
Drugs
Diseases		Deafness, autosomal recessive Erythrokeratodermia variabilis Deafness, autosomal dominant
GWAS		Intraocular pressure ( 30591961) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Headache ( 29397368) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver iron content ( 34128465) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 19571809) Smoking initiation ( 33082346) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: BTN2A2 CNST COMT ELAVL1 GIMAP5 IGFBP5 LAT LHFPL5 MFSD11 RPRM SERP1 TJP1 TMEM97 TMUB2 TRARG1	46 interacting genes: AQP6 ARL13B BIK CD53 CD79A CISD2 CREB3 EBP ELOVL4 EMP1 ERGIC3 EVI2B FAM209A FATE1 FFAR2 GJB3 GPR42 GPRC5D GPX8 HSD3B7 KIR2DL3 LHFPL5 LMNA MRM3 MUC1 PEX12 PSMA3 SEC11C SLC10A1 SLC10A6 SLC14A1 SLC16A2 SLC18A1 SLC1A3 SLC30A4 SLC35H1 SLC39A2 SPNS3 STX1A SYT1 TMEM14B TMEM179B TMEM237 TMEM31 TMEM52B TMX2
Entrez ID		2707	10385
HPRD ID		04505	12545
Ensembl ID		ENSG00000188910	ENSG00000124508
Uniprot IDs		O75712	Q8WVV5
PDB IDs			8IH4
Enriched GO Terms of Interacting Partners?			Membrane Transmembrane Transport Protein Binding Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Neurotransmitter Transport
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