PPP3CA and GABRB2

Number of citations of the paper that reports this interaction (PubMedID 12574411)
56

Data Source:
HPRD (in vitro)

		PPP3CA	GABRB2
Description		protein phosphatase 3 catalytic subunit alpha	gamma-aminobutyric acid type A receptor subunit beta2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Chloride Channel Complex Dendritic Spine Synapse Postsynaptic Membrane Extracellular Exosome GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Neuron Development Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Myristic acid	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Ginkgo biloba Glutethimide Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Fospropofol Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)	Multisite chronic pain ( 31194737 33830993) Nicotine dependence symptom count ( 25555482) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119	5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1
Entrez ID		5530	2561
HPRD ID		00234	02578
Ensembl ID		ENSG00000138814	ENSG00000145864
Uniprot IDs		A0A0S2Z4B5 A0A0S2Z4C6 Q08209	P47870
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G	6D6T 6D6U 6X3S 6X3T 6X3U 6X3V 6X3W 6X3X 6X3Z 6X40 7T0W 7T0Z 8DD2 8DD3 8SGO 8SI9 8SID 8VQY 8VRN 9CRS 9CRV 9CSB 9CT0 9CTJ 9CTP 9CTV 9CXA 9CXB 9CXC 9CXD 9DRX
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process	Negative Regulation Of Transmembrane Transport GABA Receptor Binding Myosin Binding Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Dendrite Morphogenesis Regulation Of Synaptic Vesicle Exocytosis Establishment Of Protein Localization Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Saliva Secretion Negative Regulation Of Nervous System Development Peptidyl-serine Dephosphorylation Dendritic Spine Regulation Of Intracellular Signal Transduction Negative Regulation Of Neurogenesis Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Dendritic Transport Of Mitochondrion Regulation Of Anatomical Structure Morphogenesis Regulation Of Exocytosis Negative Regulation Of Cell Projection Organization Protein Kinase C Signaling Symmetric Synapse Endomembrane System Organization Cytoplasmic Vesicle Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Macromolecule Metabolic Process Regulation Of Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Transition Between Fast And Slow Fiber Calcium Ion Transport Cell Projection Morphogenesis Positive Regulation Of Kidney Development
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