PPP3CA and C16orf74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		PPP3CA	C16orf74
Description		protein phosphatase 3 catalytic subunit alpha	chromosome 16 open reading frame 74
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Myristic acid
Diseases
GWAS		Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Type 2 diabetes ( 26818947)
Interacting Genes		44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119	2 interacting genes: PPP3CA UNC119
Entrez ID		5530	404550
HPRD ID		00234	14460
Ensembl ID		ENSG00000138814	ENSG00000154102
Uniprot IDs		A0A0S2Z4B5 A0A0S2Z4C6 Q08209	Q96GX8
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process	Negative Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcineurin Complex Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Kidney Development Positive Regulation Of Saliva Secretion Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Glomerulus Development Positive Regulation Of Calcium Ion Import Across Plasma Membrane Transition Between Fast And Slow Fiber Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Regulation Of Vesicle-mediated Transport Protein Serine/threonine Phosphatase Complex Negative Regulation Of Transport Peptidyl-serine Dephosphorylation Extrinsic Component Of Plasma Membrane Calmodulin-dependent Protein Phosphatase Activity Regulation Of Endocytosis Regulation Of Saliva Secretion Negative Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Connective Tissue Replacement Regulation Of Skeletal Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Connective Tissue Replacement Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Digestive System Process Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurotransmitter Secretion Skeletal Muscle Tissue Regeneration Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Renal Filtration Positive Regulation Of Calcium Ion-dependent Exocytosis Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Tissue Remodeling Calcineurin-NFAT Signaling Cascade Lipoprotein Transport Regulation Of Clathrin-dependent Endocytosis Renal Sodium Ion Transport Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Activated T Cell Proliferation
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