PPP3CA and RCAN1

Number of citations of the paper that reports this interaction (PMID 10861295)
100

Data Source:
HPRD (in vitro, in vivo)

		PPP3CA	RCAN1
Gene Name		protein phosphatase 3, catalytic subunit, alpha isozyme	regulator of calcineurin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma	Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Regulation Of Transcription, DNA-templated Signal Transduction Central Nervous System Development Blood Circulation Calcium-mediated Signaling
Pathways		Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1	7 interactors: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA UXT
Entrez ID		5530	1827
HPRD ID		00234	04226
Ensembl ID		ENSG00000138814	ENSG00000159200
Uniprot IDs		Q08209	P53805 Q6FGP2
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death	Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cardiac Muscle Hypertrophy Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Cellular Response To Heat Cellular Protein Modification Process Regulation Of Kinase Activity Regulation Of Binding Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Myotube Differentiation Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Heat Activation Of MAPKK Activity System Development Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Regulation Of Intracellular Transport Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of RNA Metabolic Process Immune Response Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation flna heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?