NFATC2 and EGR1

Number of citations of the paper that reports this interaction (PMID 12560487)
30

Data Source:
HPRD (in vitro)

		NFATC2	EGR1
Gene Name		nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	early growth response 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Ribonucleoprotein Complex Nuclear Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Cell Migration Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Amphetamine Transcription From RNA Polymerase II Promoter Learning Or Memory Circadian Rhythm Response To Glucose Cytokine-mediated Signaling Pathway T Cell Differentiation BMP Signaling Pathway Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Sumoylation Response To Carbon Monoxide Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Cocaine Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Long-term Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Response To Electrical Stimulus Long-term Synaptic Potentiation Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Antibiotic Cellular Response To Mechanical Stimulus Cellular Response To Isoquinoline Alkaloid Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Response To Norepinephrine Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System	Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 JUN MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ	20 interactors: CDKN2A CEBPB CREBBP CSNK2A1 EP300 ERBB3 IL1B JUN NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1
Entrez ID		4773	1958
HPRD ID		02730	00549
Ensembl ID		ENSG00000101096	ENSG00000120738
Uniprot IDs		B5B2P0 B5B2P2 B5B2P3 B5B2P4 Q13469	P18146 Q546S1
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Immune Response Regulation Of Metabolic Process Defense Response Innate Immune Response Positive Regulation Of Interleukin-4 Production Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Signaling Cell Activation Regulation Of Interleukin-4 Production Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Leukocyte Activation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Regulation Of Signal Transduction Gene Expression Regulation Of CD4-positive, Alpha-beta T Cell Differentiation N-terminal Peptidyl-lysine Acetylation Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cytokine Production Internal Protein Amino Acid Acetylation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Acetylation Leukocyte Differentiation Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway T Cell Differentiation Positive Regulation Of Cytokine Production RNA Metabolic Process Regulation Of Apoptotic Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Cell Differentiation Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Developmental Process Negative Regulation Of Apoptotic Process Immune System Process Negative Regulation Of Programmed Cell Death Immune Response Negative Regulation Of Cell Death Cellular Metabolic Process Positive Regulation By Host Of Viral Transcription Anatomical Structure Morphogenesis
Tagcloud ?		calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf	acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream
Tagcloud (Difference) ?		calcineurin deacetylases directs eliminating erk glp hat hdac hdac3 hdacs import inhibiting interfering islet islets jnk knocking mapks p38 pancreatic preserving promoters repressed selectively stability suppressing switch tnf	acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream
Tagcloud (Intersection) ?