NFATC2 and PPP3CB

Number of citations: 0 (PubMedID 9660947)
Data Source: HPRD (in vitro, in vivo)

		NFATC2	PPP3CB
Name		nuclear factor of activated T cells 2	protein phosphatase 3 catalytic subunit beta
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Transcription Factor AP-1 Complex Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Z Disc T-tubule Glutamatergic Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Phosphatase Binding Sequence-specific DNA Binding Molecular Adaptor Activity 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Response To Xenobiotic Stimulus Gene Expression Positive Regulation Of Gene Expression Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Cartilage Development Cellular Response To Calcium Ion LncRNA Transcription Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation	T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Response To Stress Lysosome Organization Signal Transduction Heart Development Learning Memory Regulation Of Gene Expression Dephosphorylation Calcium-ion Regulated Exocytosis Negative Regulation Of Signaling T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Skeletal Muscle Fiber Development Regulation Of Insulin Secretion Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Lysosome Organization Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
GWAS		A body shape index ( 34021172 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655 ) Asthma ( 32296059 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Height ( 28552196 ) Lymphocyte count ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Molar-incisor hypomineralization ( 23918034 ) Self-reported allergy ( 23817569 ) Sitting height ratio ( 25865494 ) Sum eosinophil basophil counts ( 27863252 ) Systolic blood pressure ( 30224653 ) Tourette's syndrome or obsessive-compulsive disorder ( 25158072 ) Type 2 diabetes ( 30718926 32499647 ) Urinary uric acid excretion ( 31993563 ) Weight ( 28552196 ) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: SNIP1	1 novel interactors: PRICKLE1
Interacting Genes		20 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP NRON PIN1 PPP3CB PPP3R1 PRKCZ SOCS3 TAF9 VIM YWHAQ YWHAZ	20 interacting genes: AATK CABIN1 EGFR FBXL17 IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 RCAN1 ROR2 RUNX1 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		4773	5532
HPRD ID		02730	00235
Ensembl ID		ENSG00000101096	ENSG00000107758
Uniprot IDs		B5B2P4 Q13469	B7Z781 P16298
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF 8OW4 8R07 8R3F	4OR9 4ORA 4ORC
GO Terms Enriched among Interactors		Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Biosynthetic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of RNA Metabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Macromolecule Metabolic Process T Cell Lineage Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of T-helper Cell Differentiation T-helper 17 Cell Lineage Commitment Positive Regulation Of Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Localization To Nucleus T-helper Cell Lineage Commitment Histone H3K27 Acetyltransferase Activity Mononuclear Cell Differentiation DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of CD4-positive, Alpha-beta T Cell Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Interleukin-4 Production Leukocyte Differentiation Histone Acetyltransferase Activity Regulation Of Interleukin-4 Production Lymphocyte Differentiation Lymphocyte Activation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Tau Protein Binding Phosphoserine Residue Binding Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cell Differentiation	Calcium:sodium Antiporter Activity Eyelid Development In Camera-type Eye Striated Muscle Cell Development Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Regulation Of Cardiac Conduction Muscle Cell Development Regulation Of Signal Transduction Calcium Ion Import Regulation Of Calcineurin-mediated Signaling Calcium Ion Export Across Plasma Membrane FATZ Binding Negative Regulation Of Signal Transduction Protein Phosphatase Inhibitor Activity Transcription Factor AP-1 Complex Protein Kinase Activity Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Telethonin Binding Axon Terminus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Export Across Plasma Membrane Neuronal Cell Body Axon Negative Regulation Of Cardiocyte Differentiation Calcium Ion Transport Into Cytosol Negative Regulation Of Calcineurin-NFAT Signaling Cascade Calcium Ion Transmembrane Import Into Cytosol Cellular Developmental Process Regulation Of Calcium-mediated Signaling Inorganic Cation Import Across Plasma Membrane Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Synapse Organization Postsynaptic Density Transcription Cis-regulatory Region Binding Calcineurin-NFAT Signaling Cascade Learning Or Memory Regulation Of Intracellular Signal Transduction Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Smooth Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Sarcolemma Memory Intracellular Signaling Cassette Response To Muscle Stretch Coronary Vasculature Development