NFATC2 and NRON

Number of citations of the paper that reports this interaction (PubMedID 37382239)
47

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		NFATC2	NRON
Description		nuclear factor of activated T cells 2	non-coding repressor of NFAT
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Transcription Factor AP-1 Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Phosphatase Binding Sequence-specific DNA Binding Molecular Adaptor Activity 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Response To Xenobiotic Stimulus Gene Expression Positive Regulation Of Gene Expression Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Cartilage Development Cellular Response To Calcium Ion LncRNA Transcription Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 28552196) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 30718926 32499647) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)	Bipolar disorder ( 31043756) Eyebrow thickness ( 26926045) Malaria ( 31844061)
Interacting Genes		20 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP NRON PIN1 PPP3CB PPP3R1 PRKCZ SOCS3 TAF9 VIM YWHAQ YWHAZ	8 interacting genes: HNRNPU KHSRP MATR3 MDM2 MDM4 NFATC2 NUMB TP53
Entrez ID		4773	641373
HPRD ID		02730
Ensembl ID		ENSG00000101096
Uniprot IDs		B5B2P4 Q13469
PDB IDs		1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF 8OW4 8R07 8R3F
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Biosynthetic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of RNA Metabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Macromolecule Metabolic Process T Cell Lineage Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of T-helper Cell Differentiation T-helper 17 Cell Lineage Commitment Positive Regulation Of Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Localization To Nucleus T-helper Cell Lineage Commitment Histone H3K27 Acetyltransferase Activity Mononuclear Cell Differentiation DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of CD4-positive, Alpha-beta T Cell Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Interleukin-4 Production Leukocyte Differentiation Histone Acetyltransferase Activity Regulation Of Interleukin-4 Production Lymphocyte Differentiation Lymphocyte Activation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Tau Protein Binding Phosphoserine Residue Binding Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cell Differentiation	Heart Valve Development Ventricular Septum Development Cellular Response To Actinomycin D Response To Actinomycin D Cardiac Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV-C Transcription Repressor Complex Atrial Septum Development Cellular Response To Antibiotic Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Cellular Response To Hypoxia Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Decreased Oxygen Levels Endocardial Cushion Morphogenesis Signal Transduction In Response To DNA Damage Atrioventricular Valve Morphogenesis Cellular Response To Oxygen Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Disordered Domain Specific Binding Cellular Response To Gamma Radiation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process 14-3-3 Protein Binding Regulation Of ATP-dependent Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Ribonucleoprotein Complex Binding Negative Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Biological Quality Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Response To Xenobiotic Stimulus DNA Damage Response Response To Hypoxia Response To Gamma Radiation
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