TMSB4X and ACTA2

Number of citations of the paper that reports this interaction (PMID 11812134)
9

Data Source:
HPRD (in vitro)

		TMSB4X	ACTA2
Gene Name		thymosin beta 4, X-linked	actin, alpha 2, smooth muscle, aorta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoskeleton Platelet Alpha Granule Lumen	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Smooth Muscle Contractile Fiber Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Monomer Binding Protein Binding Poly(A) RNA Binding	ATP Binding Protein Kinase Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Blood Coagulation Platelet Activation Sequestering Of Actin Monomers	Muscle Contraction Regulation Of Blood Pressure Response To Virus Vascular Smooth Muscle Contraction Glomerular Mesangial Cell Development
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Smooth Muscle Contraction
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		29 interactors: ACTA1 ACTA2 ACTB ACTG1 ALAS1 ANXA7 APLP1 CDKN1A FAM118B GRB7 IGSF21 ILK KRT13 KRT15 KRT31 KRT40 LIMS1 PNMA1 PPP4C RAD21 RBPMS SCHIP1 SMN1 TAF1D TGM2 TK1 TRIM23 TRIM27 TRIP6	16 interactors: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SHBG SNTA1 TMSB4X YBX1
Entrez ID		7114	59
HPRD ID		02153	00031
Ensembl ID		ENSG00000205542	ENSG00000107796
Uniprot IDs		A2VCK8 P62328 Q0P5T0	D2JYH4 P62736
PDB IDs		1UY5 3TU5
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Cell Junction Assembly Platelet Aggregation Anatomical Structure Development Response To Stimulus Cell Aging Cell-cell Junction Organization Hemostasis Protein Oligomerization Epithelium Development Adherens Junction Organization Developmental Process Tissue Development Regulation Of Body Fluid Levels Cell-matrix Adhesion Regulation Of Protein Import Into Nucleus Blood Coagulation Cellular Response To Stimulus Platelet Activation Fetal Process Involved In Parturition Regulation Of Protein Localization To Nucleus Cell Adhesion Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Nucleocytoplasmic Transport Cell-substrate Adhesion Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Multicellular Organismal Development Retina Homeostasis Response To Organic Cyclic Compound Single Organismal Cell-cell Adhesion Negative Regulation Of Interleukin-2 Secretion Skeletal Muscle Cell Proliferation Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Skeletal Muscle Fiber Adaptation Negative Regulation Of Gene Expression System Development Regulation Of Intracellular Protein Transport Phagocytosis Organ Development Fc Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Myofibril Assembly Cellular Response To Norepinephrine Stimulus Wound Healing Negative Regulation Of Transferase Activity Regulation Of Protein Transport Protein Complex Assembly	N-terminal Peptidyl-lysine Acetylation Regulation Of Actin Filament-based Process N-terminal Protein Amino Acid Acetylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Coagulation N-terminal Protein Amino Acid Modification Hemostasis Negative Regulation Of Cytoskeleton Organization Regulation Of Cellular Response To Heat Platelet Activation Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Toxin Transport Binding Of Sperm To Zona Pellucida Positive Regulation Of Dephosphorylation Regulation Of Body Fluid Levels Sperm-egg Recognition Wound Healing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of MAPK Cascade Regulation Of DNA-templated Transcription In Response To Stress Muscle System Process 'de Novo' Posttranslational Protein Folding Actin Filament-based Process Histone H2B Acetylation Positive Regulation Of Phospholipid Scramblase Activity Skeletal Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process ERBB2-ERBB3 Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Primary Spermatocyte Growth 'de Novo' Protein Folding Developmental Process Cellular Response To Heat Cell Activation Cell-cell Recognition Termination Of Signal Transduction Response To Wounding Rhythmic Process Platelet Degranulation Negative Regulation Of Actin Filament Polymerization Regulation Of Cellular Component Size Positive Regulation Of Type I Interferon Production Positive Regulation Of Phospholipid Catabolic Process Glucosylceramide Catabolic Process ERBB2 Signaling Pathway
Tagcloud ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim
Tagcloud (Difference) ?		aldo3 bhlhb2 bnip3 bnip31 cdknla cnn2 cobalt eno2 exerting f10 fdr hk2 itga4 lgals3 mcam mimicry mxil nominal nppb pfkp pkp2 probesets sap30 selenbpl singular u74av2 unsupervised vegfa wise	attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim
Tagcloud (Intersection) ?