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CYLD and ITCH
Number of citations of the paper that reports this interaction (PubMedID
22057290
)
49
Data Source:
BioGRID
(pull down)
CYLD
ITCH
Description
CYLD lysine 63 deubiquitinase
itchy E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Midbody
Centriolar Satellite
Ciliary Basal Body
Cell Projection
Organelle
Perinuclear Region Of Cytoplasm
Ciliary Tip
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Endosome Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Extracellular Exosome
Cell Periphery
Molecular Function
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Zinc Ion Binding
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
K63-linked Deubiquitinase Activity
Met1-linked Polyubiquitin Deubiquitinase Activity
Proline-rich Region Binding
K48-linked Deubiquitinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Biological Process
Immune System Process
Proteolysis
Canonical NF-kappaB Signal Transduction
Regulation Of Mitotic Cell Cycle
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Deubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Innate Immune Response
Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Negative Regulation Of JNK Cascade
Homeostasis Of Number Of Cells
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Necroptotic Process
Necroptotic Process
Regulation Of Microtubule Cytoskeleton Organization
Protein K63-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Ripoptosome Assembly Involved In Necroptotic Process
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Cilium Assembly
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Protein Localization
Protein Linear Deubiquitination
Negative Regulation Of Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Protein Polyubiquitination
Regulation Of Cell Growth
Immune System Process
Positive Regulation Of T Cell Anergy
Negative Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Inflammatory Response
Response To Oxidative Stress
Positive Regulation Of Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Protein Catabolic Process
Receptor Internalization
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
CD4-positive, Alpha-beta T Cell Proliferation
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
CXCL12-activated CXCR4 Signaling Pathway
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Symbiont Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Negative Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein Autoubiquitination
Regulation Of Necroptotic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Protein Branched Polyubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of Receptor Catabolic Process
Pathways
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Regulation of necroptotic cell death
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Brooke-Spiegler syndrome
Multiple familial trichoepithelioma
Familial cylindromatosis
GWAS
Adventurousness (
30643258
)
Asthma (childhood onset) (
31036433
)
Asthma (time to onset) (
27130862
)
Body mass index (
28892062
)
Crohn's disease (
22412388
28067908
)
Femoral neck bone mineral density (
29499414
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
28067908
)
Leprosy (
22019778
25642632
)
Lumbar spine bone mineral density (
22504420
29499414
)
Serum metabolite levels (
33031748
)
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31015462
31152163
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Hip circumference adjusted for BMI (
34021172
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Interacting Genes
29 interacting genes:
AKT1
CENPV
DLG4
DYRK1A
GRIA1
GRIA2
HDAC6
IKBKE
IKBKG
ITCH
KLHL21
MAP3K7
MAPK3
MAPRE1
MIB2
MLKL
PLK4
PTPA
RIGI
RNF166
TBK1
TRAF2
TRAF6
TRAF7
TRAIP
TRIM47
TUBA1A
UBC
UBE2S
132 interacting genes:
AGO2
AKT1
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DSCR9
DTX1
DTX3L
ERBB4
ESS2
EWSR1
FYN
GJA1
GLIS3
GNAI2
H1-2
HNRNPUL1
JUN
JUNB
KIAA1210
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2
MAP2K1
MAP2K4
MAP3K2
MAPK8
MLANA
MLKL
MYCT1
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
PIP4P2
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RBM14
REPS2
RHBDD1
RIPK1
RNF11
RORA
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SIK1
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
SPEN
STAM2
STRIP2
SUFU
TAB1
TAF15
TGFB1I1
TMEM51
TP73
TRERF1
TRPC4
TRPV1
TRPV4
TTYH3
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
UVRAG
WASL
WBP2
YWHAQ
YY1
ZC3H14
Entrez ID
1540
83737
HPRD ID
05427
07565
Ensembl ID
ENSG00000083799
ENSG00000078747
Uniprot IDs
Q9NQC7
Q96J02
PDB IDs
1IXD
1WHL
1WHM
2VHF
7OWC
7OWD
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
Enriched GO Terms of Interacting Partners
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Protein Modification Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Transferase Activity
Ubiquitin-protein Transferase Activity
Post-translational Protein Modification
Regulation Of Type I Interferon Production
Identical Protein Binding
Protein K29-linked Ubiquitination
Protein Polyubiquitination
Cell Surface Receptor Signaling Pathway
Cytosol
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Cytoplasm
Protein Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Activity
Cytokine-mediated Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Activation Of Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Protein Metabolic Process
Innate Immune Response-activating Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Innate Immune Response
Ubiquitin Protein Ligase Binding
Positive Regulation Of Defense Response
Positive Regulation Of Signal Transduction
Positive Regulation Of Macroautophagy
Toll-like Receptor 4 Signaling Pathway
Regulation Of Macroautophagy
Anoikis
Positive Regulation Of Immune Response
Macromolecule Metabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Programmed Cell Death
Immune Response-activating Signaling Pathway
Cell Death
Intracellular Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Cell Communication
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Nucleus
Cytosol
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
ATP Binding
Transferase Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
WW Domain Binding
Regulation Of Primary Metabolic Process
Protein Binding
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Intracellular Signaling Cassette
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Cell Differentiation
Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Ubiquitination
Negative Regulation Of Metabolic Process
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Tagcloud (Intersection)
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