CYLD and KLHL21

Number of citations of the paper that reports this interaction (PubMedID 36538852)
0

Data Source:
BioGRID (pull down)

		CYLD	KLHL21
Description		CYLD lysine 63 deubiquitinase	kelch like family member 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Cell Projection Organelle Perinuclear Region Of Cytoplasm Ciliary Tip	Cytoplasm Spindle Polar Microtubule Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Protein Kinase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Met1-linked Polyubiquitin Deubiquitinase Activity Proline-rich Region Binding K48-linked Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Immune System Process Proteolysis Canonical NF-kappaB Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Negative Regulation Of JNK Cascade Homeostasis Of Number Of Cells Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Necroptotic Process Necroptotic Process Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Protein Localization Protein Linear Deubiquitination Negative Regulation Of Interleukin-18-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Ubiquitination Regulation Of Cytokinesis Chromosome Passenger Complex Localization To Spindle Midzone Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Brooke-Spiegler syndrome Multiple familial trichoepithelioma Familial cylindromatosis
GWAS		Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 22412388 28067908) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 22019778 25642632) Lumbar spine bone mineral density ( 22504420 29499414) Serum metabolite levels ( 33031748)	Appendicular lean mass ( 33097823)
Interacting Genes		29 interacting genes: AKT1 CENPV DLG4 DYRK1A GRIA1 GRIA2 HDAC6 IKBKE IKBKG ITCH KLHL21 MAP3K7 MAPK3 MAPRE1 MIB2 MLKL PLK4 PTPA RIGI RNF166 TBK1 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S	5 interacting genes: AURKB CYLD IKBKB KLC3 MAPRE1
Entrez ID		1540	9903
HPRD ID		05427	17239
Ensembl ID		ENSG00000083799	ENSG00000162413
Uniprot IDs		Q9NQC7	Q9UJP4
PDB IDs		1IXD 1WHL 1WHM 2VHF 7OWC 7OWD
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of Type I Interferon Production Identical Protein Binding Protein K29-linked Ubiquitination Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Cytosol Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Cytoplasm Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process Activation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Positive Regulation Of Macroautophagy Toll-like Receptor 4 Signaling Pathway Regulation Of Macroautophagy Anoikis Positive Regulation Of Immune Response Macromolecule Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Programmed Cell Death Immune Response-activating Signaling Pathway Cell Death Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cell Communication	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Pattern Recognition Receptor Signaling Pathway Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Intracellular Receptor Signaling Pathway Activation Of Innate Immune Response Spindle Midzone Regulation Of Microtubule-based Process Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Innate Immune Response Microtubule Immune Response-activating Signaling Pathway Cytoplasmic Microtubule Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Defense Response Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Cytoskeleton Organization Met1-linked Polyubiquitin Deubiquitinase Activity Cytoskeleton Spindle Assembly Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Astral Microtubule Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Immune Response Centrosome Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Microtubule Cytoskeleton Organization Involved In Mitosis Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Protein Linear Deubiquitination Negative Regulation Of Intracellular Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent IkappaB Kinase Activity Spindle Pole Mitotic Spindle Astral Microtubule End Cortical Microtubule Cytoskeleton Spindle Organization Microtubule-based Process
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