SMU1 and TLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMU1	TLX3
Description		SMU1 DNA replication regulator and spliceosomal factor	T cell leukemia homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Aspartate aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Body size at age 10 ( 32376654)
Interacting Genes		12 interacting genes: CD2BP2 CEBPA CERT1 H2BC21 LSM4 LSM8 MRFAP1 MSS51 RASSF10 TLX3 UBC YBX1	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		55234	30012
HPRD ID		11588	06868
Ensembl ID		ENSG00000122692	ENSG00000164438
Uniprot IDs		A0MNN4 Q2TAY7	O43711
PDB IDs		5O9Z 6AHD 6Q8F 6Q8I 6Q8J 8H6K 8H6L 8QO9 8QZS
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Lsm2-8 Complex U6 SnRNP U6 SnRNA Binding RNA Splicing MRNA Processing Spliceosomal SnRNP Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Metabolic Process Intermembrane Sphingolipid Transfer U2-type Precatalytic Spliceosome Response To Vitamin B2 C/EBP Complex Ceramide Transfer Activity CHOP-C/EBP Complex RNA Metabolic Process P-body RNA Processing Ribonucleoprotein Complex MiRNA Transport ER To Golgi Ceramide Transport	Intermediate Filament Protein Binding Chromatin
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