ALDOB and FLCN

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ALDOB	FLCN
Description		aldolase, fructose-bisphosphate B	folliculin
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Centriolar Satellite Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Midbody Cell Projection Cell-cell Contact Zone Mitotic Spindle FNIP-folliculin RagC/D GAP
	Molecular Function	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity Identical Protein Binding ATPase Binding Molecular Adaptor Activity Fructose-1-phosphate Aldolase Activity Fructose Binding	Enzyme Inhibitor Activity GTPase Activator Activity Protein Binding Enzyme Binding Protein-containing Complex Binding
	Biological Process	Fructose Metabolic Process Fructose Catabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Vacuolar Proton-transporting V-type ATPase Complex Assembly Negative Regulation Of Pentose-phosphate Shunt	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lysosome Organization Cell-cell Junction Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Hemopoiesis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels TOR Signaling Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Lysosome Localization Cellular Response To Amino Acid Starvation Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Ras Protein Signal Transduction Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cell Proliferation Involved In Kidney Development Energy Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Brown Fat Cell Differentiation Positive Regulation Of TORC1 Signaling Negative Regulation Of Lysosome Organization Regulation Of Pro-B Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Hereditary fructose intolerance Glycolysis Gluconeogenesis Fructose catabolism	Amino acids regulate mTORC1
Drugs		1,6-Fructose Diphosphate (Linear Form) sn-glycerol 3-phosphate Dihydroxyacetone phosphate
Diseases		Hereditary fructose intolerance; Fructosemia	Birt-Hogg-Dube syndrome Renal cell carcinoma
GWAS		Age-related cataracts ( 25352737) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Serum alkaline phosphatase levels ( 29403010 33339817 33547301)	Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494)
Interacting Genes		22 interacting genes: AGXT2 APP ATP6V1E1 BMPR1A BUB1 CDKN2A CTNNA1 DCC FLCN HIVEP1 HSPA8 MAP2K4 MCC MLH1 MLH3 MUC20 NRAS SMAD4 SRC STK11 TXN2 USP40	12 interacting genes: ALDOB APP CCDC180 FBP1 GABARAP HEMGN HSP90AA1 MAP1LC3B NANS RRAGA TMEFF1 TSTD2
Entrez ID		229	201163
HPRD ID		01972	06278
Ensembl ID		ENSG00000136872	ENSG00000154803
Uniprot IDs		P05062	A0A0S2Z5Y7 Q8NFG4
PDB IDs		1QO5 1XDL 1XDM 8D44	3V42 6NZD 6ULG 8DHB
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process Chiasma Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Import Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Homeostatic Process Mismatch Repair Complex Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Mesendoderm Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of Glycolytic Process Signaling Receptor Activator Activity Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Negative Regulation Of Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Epithelial Cell Proliferation Cellular Response To Stress Apoptotic Process Regulation Of Growth Regulation Of Carbohydrate Catabolic Process Cytosol Mismatched DNA Binding Regulation Of Protein Stability Regulation Of Protein Localization Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Regulation Of ATP Metabolic Process Enzyme Binding Regulation Of MiRNA Transcription Negative Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Reproductive Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Cell Differentiation	Fructose Metabolic Process Regulation Of Carbohydrate Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagosome Assembly Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Carbohydrate Biosynthetic Process Response To Salt Stress Regulation Of Generation Of Precursor Metabolites And Energy Vacuole Organization Response To Nutrient Levels Cellular Response To Starvation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Fructose-1-phosphate Aldolase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP CTP Binding DATP Binding Response To Starvation Cellular Response To Nutrient Levels Autophagosome Membrane Autophagosome Maturation N-acetylneuraminate Synthase Activity N-acylneuraminate-9-phosphate Synthase Activity Mitophagy Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Autophagy Regulation Of Small Molecule Metabolic Process Negative Regulation Of Pentose-phosphate Shunt Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Osmotic Stress Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity
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