AHSA1 and CLCN1

Number of citations of the paper that reports this interaction (PubMedID 27580824)
60

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AHSA1	CLCN1
Description		activator of HSP90 ATPase activity 1	chloride voltage-gated channel 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Exosome	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex Chloride Channel Complex Sarcolemma
	Molecular Function	ATPase Activator Activity Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Protein Homodimerization Activity
	Biological Process	Protein Folding Positive Regulation Of ATP-dependent Activity Maintenance Of Unfolded Protein	Monoatomic Ion Transport Chloride Transport Muscle Contraction Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways			Stimuli-sensing channels
Drugs
Diseases			Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal recessive myotonia congenita (Becker disease); Fluctuating myotonia congenita; Myotonia levoir
GWAS
Interacting Genes		12 interacting genes: AKT1 APP CEBPA CLCN1 EGFR FILNC1 FKBP4 GCH1 HSP90AA1 OGT PTGES3 USP40	7 interacting genes: AHSA1 APPBP2 CIDEB FAM9B FKBP8 PRDM5 STIP1
Entrez ID		10598	1180
HPRD ID		09768	00320
Ensembl ID		ENSG00000100591	ENSG00000188037
Uniprot IDs		G3V438 O95433	P35523
PDB IDs		1X53 7DMD 7DME	6COY 6COZ 6QV6 6QVB 6QVC 6QVD 6QVU 8WXI 8WXJ
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Regulation Of Protein Catabolic Process Reactive Nitrogen Species Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Homodimerization Activity Positive Regulation Of Proteolysis Nitric-oxide Synthase Regulator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Response To UV-A Positive Regulation Of DNA Metabolic Process Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Biological Quality Regulation Of Proteolysis Response To Tumor Necrosis Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Axonal Growth Cone RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Nucleus Regulation Of Peptidyl-serine Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Regulation Of Protein Localization To Membrane Positive Regulation Of Defense Response Positive Regulation Of Protein Localization Cellular Response To Metal Ion Regulation Of Superoxide Metabolic Process System Process Nervous System Process Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Regulation Of Protein Localization Regulation Of Protein Metabolic Process	Hsp90 Protein Binding Protein Folding Chaperone
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