AHSA1 and GCH1

Number of citations of the paper that reports this interaction (PubMedID 16696853)
38

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid)

		AHSA1	GCH1
Description		activator of HSP90 ATPase activity 1	GTP cyclohydrolase 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	ATPase Activator Activity Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Protein Folding Positive Regulation Of ATP-dependent Activity Maintenance Of Unfolded Protein	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS			Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		12 interacting genes: AKT1 APP CEBPA CLCN1 EGFR FILNC1 FKBP4 GCH1 HSP90AA1 OGT PTGES3 USP40	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		10598	2643
HPRD ID		09768	02573
Ensembl ID		ENSG00000100591	ENSG00000131979
Uniprot IDs		G3V438 O95433	P30793 Q8IZH9
PDB IDs		1X53 7DMD 7DME	1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Regulation Of Protein Catabolic Process Reactive Nitrogen Species Metabolic Process Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Homodimerization Activity Positive Regulation Of Proteolysis Nitric-oxide Synthase Regulator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Response To UV-A Positive Regulation Of DNA Metabolic Process Kinase Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Biological Quality Regulation Of Proteolysis Response To Tumor Necrosis Factor Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Axonal Growth Cone RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Nucleus Regulation Of Peptidyl-serine Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Embryonic Organ Development Regulation Of Protein Localization To Membrane Positive Regulation Of Defense Response Positive Regulation Of Protein Localization Cellular Response To Metal Ion Regulation Of Superoxide Metabolic Process System Process Nervous System Process Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Regulation Of Protein Localization Regulation Of Protein Metabolic Process	Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding
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