DCUN1D2 and UBE2M

Number of citations of the paper that reports this interaction (PubMedID 28581483)
60

Data Source:
BioGRID (pull down)

		DCUN1D2	UBE2M
Description		defective in cullin neddylation 1 domain containing 2	ubiquitin conjugating enzyme E2 M
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity
	Biological Process	Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly
Pathways		Neddylation	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		7 interacting genes: APP CAND1 CUL2 CUL3 MAP3K1 UBE2F UBE2M	34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		55208	9040
HPRD ID		12614	04414
Ensembl ID		ENSG00000150401	ENSG00000130725
Uniprot IDs		Q6PH85	A0A024R4T4 P61081
PDB IDs		4GAO	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex NEDD8 Conjugating Enzyme Activity NEDD8 Transferase Activity Protein Modification By Small Protein Conjugation Protein Metabolic Process Protein Modification Process Ubiquitin Ligase Complex Scaffold Activity Post-translational Protein Modification Protein Neddylation Postsynapse Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Trophectodermal Cellular Morphogenesis Liver Morphogenesis Proteasomal Protein Catabolic Process SCF Complex Assembly PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Ubiquitination Mitotic Cell Cycle Phase Transition POZ Domain Binding	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process
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