DCUN1D2 and UBE2F

Number of citations of the paper that reports this interaction (PubMedID 23201271)
53

Data Source:
BioGRID (pull down)

		DCUN1D2	UBE2F
Description		defective in cullin neddylation 1 domain containing 2	ubiquitin conjugating enzyme E2 F (putative)
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Nucleotide Binding Protein Binding ATP Binding Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity NEDD8 Ligase Activity
	Biological Process	Protein Neddylation Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Protein Neddylation Defense Response To Virus
Pathways		Neddylation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)	Lean body mass ( 28552196)
Interacting Genes		7 interacting genes: APP CAND1 CUL2 CUL3 MAP3K1 UBE2F UBE2M	13 interacting genes: CUL1 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RBX1 RC3H1 RNF34 RNF7 TRIM2 UBA3
Entrez ID		55208	140739
HPRD ID		12614	14812
Ensembl ID		ENSG00000150401	ENSG00000184182
Uniprot IDs		Q6PH85	Q969M7
PDB IDs		4GAO	2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex NEDD8 Conjugating Enzyme Activity NEDD8 Transferase Activity Protein Modification By Small Protein Conjugation Protein Metabolic Process Protein Modification Process Ubiquitin Ligase Complex Scaffold Activity Post-translational Protein Modification Protein Neddylation Postsynapse Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Trophectodermal Cellular Morphogenesis Liver Morphogenesis Proteasomal Protein Catabolic Process SCF Complex Assembly PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Ubiquitination Mitotic Cell Cycle Phase Transition POZ Domain Binding	Protein Neddylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cullin Family Protein Binding Protein Modification Process NEDD8 Transferase Activity Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Neddylation NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination NEDD8 Ligase Activity Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Modifier Activating Enzyme Activity Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Macromolecule Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Modification Process Cytoplasm Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Apoptotic Process Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Stress Response To Cytokine Response To Peptide Cellular Response To Interleukin-1 Positive Regulation Of Hippocampal Neuron Apoptotic Process
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