EMILIN1 and LRRIQ1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EMILIN1	LRRIQ1
Description		elastin microfibril interfacer 1	leucine rich repeats and IQ motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix Integrin Alpha4-beta1 Complex Extracellular Exosome EMILIN Complex	Microtubule Cytoskeleton
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Molecular Adaptor Activity Integrin Binding Involved In Cell-matrix Adhesion
	Biological Process	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Platelet Aggregation Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration	Apoptotic Process Single Fertilization Regulation Of Signal Transduction Gene Expression Ectopic Germ Cell Programmed Cell Death
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Monobrow ( 27182965) Optic disc size ( 31809533)
Interacting Genes		28 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TSNAX YJU2 ZC2HC1C ZNF655	2 interacting genes: BCL2L2 EMILIN1
Entrez ID		11117	84125
HPRD ID		00563	09952
Ensembl ID		ENSG00000138080	ENSG00000133640
Uniprot IDs		Q9Y6C2	A0A140VJN5 Q96JM4
PDB IDs		2KA3 2OII
Enriched GO Terms of Interacting Partners?		A2A Adenosine Receptor Binding	Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Sertoli Cell Proliferation Bcl-2 Family Protein Complex Integrin Binding Involved In Cell-matrix Adhesion Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway EMILIN Complex Positive Regulation Of Defense Response To Bacterium Regulation Of Collagen Fibril Organization Integrin Alpha4-beta1 Complex Positive Regulation Of Platelet Aggregation Positive Regulation Of Extracellular Matrix Assembly Extracellular Matrix Constituent Conferring Elasticity Elastic Fiber Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Collagen Biosynthetic Process Regulation Of Defense Response To Bacterium Negative Regulation Of Macrophage Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Release Of Cytochrome C From Mitochondria Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Coagulation Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulation Of Platelet Aggregation Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Blood Coagulation Cell Adhesion Mediated By Integrin Extracellular Matrix Assembly Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Aortic Valve Morphogenesis Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Mononuclear Cell Migration Regulation Of Collagen Biosynthetic Process Channel Activity Regulation Of Collagen Metabolic Process Regulation Of Macrophage Migration Negative Regulation Of Leukocyte Migration Regulation Of Platelet Activation Heart Valve Morphogenesis Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Positive Regulation Of Wound Healing Negative Regulation Of ERK1 And ERK2 Cascade
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