EMILIN1 and FBXO28

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		EMILIN1	FBXO28
Description		elastin microfibril interfacer 1	F-box protein 28
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix Integrin Alpha4-beta1 Complex Extracellular Exosome EMILIN Complex	Chromosome, Centromeric Region Kinetochore Chromosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Molecular Adaptor Activity Integrin Binding Involved In Cell-matrix Adhesion	Protein Binding Identical Protein Binding
	Biological Process	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Cell Adhesion Mediated By Integrin Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Platelet Aggregation Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration	Protein Polyubiquitination
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		28 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TSNAX YJU2 ZC2HC1C ZNF655	21 interacting genes: AGGF1 CSNK2A1 CTNNA3 EMILIN1 EMILIN3 EXOC7 GCC1 GK GOLGA2 GOLGA6L9 PFKFB4 PLEKHF2 PMF1 PSMC3 SDCBP2 SNAI2 SPAG5 STX1B TOP2A TRAF2 VHL
Entrez ID		11117	23219
HPRD ID		00563	12367
Ensembl ID		ENSG00000138080	ENSG00000143756
Uniprot IDs		Q9Y6C2	Q9NVF7
PDB IDs		2KA3 2OII
Enriched GO Terms of Interacting Partners?		A2A Adenosine Receptor Binding
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