PPP1R7 and PPP1CB

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		PPP1R7	PPP1CB
Description		protein phosphatase 1 regulatory subunit 7	protein phosphatase 1 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Focal Adhesion Extracellular Exosome PTW/PP1 Phosphatase Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Myosin Phosphatase Activity Protein Kinase Binding Metal Ion Binding Myosin-light-chain-phosphatase Activity
	Biological Process		MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Regulation Of Cell Adhesion Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Rhythmic Process Cell Division
Pathways			Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Body mass index ( 25673413) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Excessive sweating ( 29895819) Heel bone mineral density ( 28869591 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Pure non-grapefruit juice consumption ( 31046077)
Interacting Genes		16 interacting genes: CLNK FER HGS MAPK6 MYH3 OGT PPP1CB PPP1CC PPP1R3A SPRED1 TAB1 TNFRSF6B UBC UBXN2B USHBP1 VCP	46 interacting genes: ACTN2 AURKA BRCA1 C14orf180 CHCHD3 CLK1 CLOCK CSNK2B CSRNP2 CYSRT1 DELEC1 FBXO7 H3-3A H3C1 HOXA2 KANK2 KIF23 LMTK2 MAPT MEOX2 NONO PHACTR3 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PPP1R27 PPP1R2B PPP1R2C PPP1R3A PPP1R3B PPP1R3C PPP1R7 PPP1R9A PPP2R5C PRKAR2A PTK2 RB1 RORC SPATC1L TLX1 TP53BP2 UBAC1 WBP11 ZFYVE9
Entrez ID		5510	5500
HPRD ID		04192	11792
Ensembl ID		ENSG00000115685	ENSG00000213639
Uniprot IDs		A0A140VK83 Q15435	P62140 V9HW04
PDB IDs		6HKW 6MKY 6OBN 6OBP 8B5R 8U5G
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein-containing Complex Myosin Phosphatase Activity Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Serine/threonine Phosphatase Activity Intracellular Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Protein-containing Complex Binding Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-like Protein Ligase Binding Photoperiodism Entrainment Of Circadian Clock Protein Modification Process Protein Exit From Endoplasmic Reticulum Cytosol Macroautophagy Protein Kinase Binding Energy Derivation By Oxidation Of Organic Compounds Endosome Transport Via Multivesicular Body Sorting Pathway Adherens Junction Disassembly Intracellular Signaling Cassette Myosin-light-chain-phosphatase Activity Flavin Adenine Dinucleotide Catabolic Process Multivesicular Body Sorting Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphate-containing Compound Metabolic Process Protein Domain Specific Binding Cytoplasm MAPK Cascade Protein Localization To Lysosome Canonical NF-kappaB Signal Transduction Regulation Of Phosphorus Metabolic Process Cell-cell Junction Disassembly Rhythmic Process Septin Cytoskeleton VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Protein Localization To Centrosome Regulation Of Protein Modification Process Kit Signaling Pathway Protein Metabolic Process Phosphatase Activity Regulation Of ATP Metabolic Process	Myosin Phosphatase Regulator Activity Protein Phosphatase Inhibitor Activity Phosphatase Regulator Activity Protein Phosphatase 1 Binding Glycogen Binding Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Phosphatase Binding Enzyme Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Glycogen Biosynthetic Process Stress Fiber Regulation Of Centromere Complex Assembly Regulation Of Glycogen Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Kinase Binding Centrosome Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromatin Cell Projection Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle A Band Segment Specification Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Process
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