PPP1R7 and UBXN2B

Number of citations of the paper that reports this interaction (PubMedID 37264685)
46

Data Source:
BioGRID (pull down)

		PPP1R7	UBXN2B
Description		protein phosphatase 1 regulatory subunit 7	UBX domain protein 2B
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Spindle Pole Centrosome
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Protein Binding Ubiquitin Binding
	Biological Process		Autophagosome Assembly Establishment Of Mitotic Spindle Orientation Golgi Organization Nuclear Membrane Reassembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Membrane Fusion Negative Regulation Of Protein Localization To Centrosome
Pathways
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Gallstone disease ( 27094239) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Loneliness ( 27629369) Low density lipoprotein cholesterol levels ( 29403010 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Narcolepsy with cataplexy ( 23496005) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		16 interacting genes: CLNK FER HGS MAPK6 MYH3 OGT PPP1CB PPP1CC PPP1R3A SPRED1 TAB1 TNFRSF6B UBC UBXN2B USHBP1 VCP	16 interacting genes: CRX INCA1 MEOX1 MEOX2 NGLY1 PAX5 PAX6 PIN1 PPP1R11 PPP1R3A PPP1R7 UBC UBXN6 VAT1L VCP XAF1
Entrez ID		5510	137886
HPRD ID		04192	18973
Ensembl ID		ENSG00000115685	ENSG00000215114
Uniprot IDs		A0A140VK83 Q15435	E5RJ36 Q14CS0
PDB IDs		6HKW 6MKY 6OBN 6OBP 8B5R 8U5G	8B5R
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein-containing Complex Myosin Phosphatase Activity Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Serine/threonine Phosphatase Activity Intracellular Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Protein-containing Complex Binding Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-like Protein Ligase Binding Photoperiodism Entrainment Of Circadian Clock Protein Modification Process Protein Exit From Endoplasmic Reticulum Cytosol Macroautophagy Protein Kinase Binding Energy Derivation By Oxidation Of Organic Compounds Endosome Transport Via Multivesicular Body Sorting Pathway Adherens Junction Disassembly Intracellular Signaling Cassette Myosin-light-chain-phosphatase Activity Flavin Adenine Dinucleotide Catabolic Process Multivesicular Body Sorting Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphate-containing Compound Metabolic Process Protein Domain Specific Binding Cytoplasm MAPK Cascade Protein Localization To Lysosome Canonical NF-kappaB Signal Transduction Regulation Of Phosphorus Metabolic Process Cell-cell Junction Disassembly Rhythmic Process Septin Cytoskeleton VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Protein Localization To Centrosome Regulation Of Protein Modification Process Kit Signaling Pathway Protein Metabolic Process Phosphatase Activity Regulation Of ATP Metabolic Process	Somite Specification Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus HMG Box Domain Binding Segment Specification Somite Development DNA-binding Transcription Factor Activity Protein Phosphatase 1 Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Cis-trans Isomerase Activity Flavin Adenine Dinucleotide Catabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Retina Development In Camera-type Eye Sclerotome Development Embryonic Pattern Specification Cerebral Cortex Development Habenula Development Pallium Development Ubiquitin Protein Ligase Binding Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Modification-dependent Protein Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Endosome To Lysosome Transport Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Asymmetric Cell Division Oligodendrocyte Cell Fate Specification Proteolysis Cytoplasm Protein Quality Control ERAD Pathway
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