PPP1R7 and FER

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		PPP1R7	FER
Description		protein phosphatase 1 regulatory subunit 7	FER tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Extracellular Exosome	Chromatin Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Lamellipodium Cell Junction Protein-containing Complex Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Enzyme Regulator Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Phosphatase 1 Binding Lipid Binding Kinase Activity Transferase Activity
	Biological Process		Microtubule Cytoskeleton Organization Regulation Of Protein Phosphorylation Protein Phosphorylation Chemotaxis Cell Adhesion Signal Transduction Tyrosine Phosphorylation Of STAT Protein Germ Cell Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Male Gonad Development Regulation Of Lamellipodium Assembly Regulation Of Fibroblast Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Involved In Immune Response Adherens Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Extracellular Matrix-cell Signaling Intracellular Signal Transduction Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Platelet-derived Growth Factor Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Diapedesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Interleukin-6-mediated Signaling Pathway Seminiferous Tubule Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Adherens Junction Disassembly Positive Regulation Of Supramolecular Fiber Organization
Pathways			Signaling by SCF-KIT
Drugs			Fostamatinib
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Adiponectin levels ( 21700879) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Early-onset Parkinson's disease ( 28256260) Height ( 25282103 20881960) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 31959993 30054594 29785010 29617998 29235454) Paneth cell defects in Crohn's disease ( 28352666) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Sepsis from pneumonia (survival) ( 25533491) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: CLNK FER HGS MAPK6 MYH3 OGT PPP1CB PPP1CC PPP1R3A SPRED1 TAB1 TNFRSF6B UBC UBXN2B USHBP1 VCP	19 interacting genes: CALM1 CDH1 CRK CTNNB1 CTNND1 CTTN EGFR ERBB2 ERBB3 IRS1 JAK1 JUP KCTD4 PIK3R1 PIK3R3 PPP1R7 STAT3 TMF1 YWHAB
Entrez ID		5510	2241
HPRD ID		04192	01491
Ensembl ID		ENSG00000115685	ENSG00000151422
Uniprot IDs		A0A140VK83 Q15435	P16591 Q6PEJ9
PDB IDs		6HKW 6MKY 6OBN 6OBP 8B5R 8U5G	2KK6 6KC4
Enriched GO Terms of Interacting Partners?		Protein Phosphatase 1 Binding Protein-containing Complex Myosin Phosphatase Activity Glycogen Metabolic Process PTW/PP1 Phosphatase Complex Circadian Regulation Of Gene Expression Energy Reserve Metabolic Process Polysaccharide Metabolic Process Protein Serine/threonine Phosphatase Activity Intracellular Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Protein-containing Complex Binding Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-like Protein Ligase Binding Photoperiodism Entrainment Of Circadian Clock Protein Modification Process Protein Exit From Endoplasmic Reticulum Cytosol Macroautophagy Protein Kinase Binding Energy Derivation By Oxidation Of Organic Compounds Endosome Transport Via Multivesicular Body Sorting Pathway Adherens Junction Disassembly Intracellular Signaling Cassette Myosin-light-chain-phosphatase Activity Flavin Adenine Dinucleotide Catabolic Process Multivesicular Body Sorting Pathway Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Phosphate-containing Compound Metabolic Process Protein Domain Specific Binding Cytoplasm MAPK Cascade Protein Localization To Lysosome Canonical NF-kappaB Signal Transduction Regulation Of Phosphorus Metabolic Process Cell-cell Junction Disassembly Rhythmic Process Septin Cytoskeleton VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Negative Regulation Of Protein Localization To Centrosome Regulation Of Protein Modification Process Kit Signaling Pathway Protein Metabolic Process Phosphatase Activity Regulation Of ATP Metabolic Process	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Cellular Response To Indole-3-methanol ErbB-3 Class Receptor Binding Cell Motility Response To Indole-3-methanol Catenin Complex Cadherin Binding Phosphotyrosine Residue Binding Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Cell Migration Insulin-like Growth Factor Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus ERBB3:ERBB2 Complex Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling ERBB Signaling Pathway Regulation Of Angiogenesis Regulation Of Cellular Localization Regulation Of Vasculature Development ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Catenin-TCF7L2 Complex Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Localization To Nucleus Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Signaling Receptor Binding Glial Cell Differentiation Negative Regulation Of Programmed Cell Death Focal Adhesion Positive Regulation Of Signal Transduction Regulation Of Nucleocytoplasmic Transport Regulation Of Developmental Process Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Regulation Of Multicellular Organismal Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?