CDCA4 and TXN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDCA4	TXN2
Description		cell division cycle associated 4	thioredoxin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Positive Regulation Of DNA-templated Transcription	Cell Redox Homeostasis
Pathways			Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)
Interacting Genes		25 interacting genes: AIRIM BFSP2 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451	78 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B CSTPP1 DCTD DDIT3 ETHE1 FAM9B FHL5 GOLGA6L9 GPRASP2 GPRASP3 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		55038	25828
HPRD ID		13015	07161
Ensembl ID		ENSG00000170779	ENSG00000100348
Uniprot IDs		Q9BXL8	Q99757
PDB IDs			1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?		Epigenetic Programming Of Gene Expression Histone H3K9 Trimethyltransferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Regulation Of DNA Repair Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Binding I Band SAGA Complex Transcription Coactivator Activity Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization	Identical Protein Binding Protein Binding Microtubule Organizing Center Organelle Organization Cytoskeleton Organization Cytoskeleton Membraneless Organelle Assembly Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Synaptonemal Complex Microtubule Cytoskeleton Organization Cytoplasm Microtubule-based Process
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