CDCA4 and TCAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDCA4	TCAP
Description		cell division cycle associated 4	titin-cap
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding
	Biological Process	Positive Regulation Of DNA-templated Transcription	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways			Striated Muscle Contraction
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)	Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		25 interacting genes: AIRIM BFSP2 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451	38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN
Entrez ID		55038	8557
HPRD ID		13015	05133
Ensembl ID		ENSG00000170779	ENSG00000173991
Uniprot IDs		Q9BXL8	A2TDC0 O15273
PDB IDs			1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Epigenetic Programming Of Gene Expression Histone H3K9 Trimethyltransferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Regulation Of DNA Repair Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Binding I Band SAGA Complex Transcription Coactivator Activity Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization	Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process
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