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USP47 and PLA2G2A
Number of citations of the paper that reports this interaction (PMID
22118674
)
23
Data Source:
BioGRID
(enzymatic study)
USP47
PLA2G2A
Gene Name
ubiquitin specific peptidase 47
phospholipase A2, group IIA (platelets, synovial fluid)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
SCF Ubiquitin Ligase Complex
Extracellular Region
Extracellular Space
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Secretory Granule
Extracellular Vesicular Exosome
Molecular Function
Cysteine-type Endopeptidase Activity
Ubiquitin-specific Protease Activity
Protein Binding
WD40-repeat Domain Binding
Phospholipase A2 Activity
Calcium Ion Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Biological Process
Base-excision Repair
Cellular Response To DNA Damage Stimulus
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Growth
Cellular Response To UV
Monoubiquitinated Protein Deubiquitination
Response To Drug
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Catabolic Process
Low-density Lipoprotein Particle Remodeling
Somatic Stem Cell Maintenance
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Small Molecule Metabolic Process
Phosphatidic Acid Metabolic Process
Glycerophospholipid Biosynthetic Process
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Pathways
Acyl chain remodelling of PG
Acyl chain remodelling of PE
Synthesis of PA
Metabolism of lipids and lipoproteins
Acyl chain remodelling of PI
Phospholipid metabolism
Glycerophospholipid biosynthesis
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Drugs
Indomethacin
Diclofenac
Ginkgo biloba
1,4-Butanediol
1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene
N-Tridecanoic Acid
[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid
4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid
1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid
6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid
Elaidoylamide
1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide
(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid
Suramin
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
AP4M1
MED29
MED9
PLA2G2A
SNCA
24 interactors:
ALOX12
BAG6
CEP70
CRMP1
DCN
JOSD2
PLA2G1B
PLA2R1
SENP6
SENP8
UCHL1
UCHL3
UCHL5
USP15
USP2
USP20
USP28
USP4
USP47
USP5
USP7
USP8
VCAN
VIM
Entrez ID
55031
5320
HPRD ID
11668
01397
Ensembl ID
ENSG00000170242
ENSG00000188257
Uniprot IDs
Q96K76
P14555
PDB IDs
1AYP
1BBC
1DB4
1DB5
1DCY
1J1A
1KQU
1KVO
1N28
1N29
1POD
1POE
2GNY
3U8B
3U8D
3U8H
3U8I
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Thrombin Receptor Signaling Pathway
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Norepinephrine Uptake
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Positive Regulation Of Glutathione Peroxidase Activity
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Negative Regulation Of Dopamine Metabolic Process
Negative Regulation Of Cellular Respiration
Negative Regulation Of Oxidative Phosphorylation
Negative Regulation Of Synaptic Transmission, Dopaminergic
Response To Iron(II) Ion
Cellular Response To Copper Ion
Regulation Of Synaptic Vesicle Recycling
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Regulation Of Oxidative Phosphorylation
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Regulation Of Hydrogen Peroxide Metabolic Process
Dopamine Transport
Regulation Of Glutamate Secretion
Dopamine Biosynthetic Process
Low-density Lipoprotein Particle Remodeling
Phospholipid Metabolic Process
Negative Regulation Of Monooxygenase Activity
Neurotransmitter Uptake
Regulation Of Cellular Respiration
Microglial Cell Activation
Extracellular Fibril Organization
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Synaptic Transmission, Dopaminergic
Behavioral Response To Cocaine
Phosphatidylinositol Acyl-chain Remodeling
Regulation Of Neurotransmitter Uptake
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Negative Regulation Of Microtubule Polymerization
Positive Regulation Of Neurotransmitter Secretion
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Acyl-CoA Biosynthetic Process
Cellular Response To Epinephrine Stimulus
Golgi To Endosome Transport
Positive Regulation Of Receptor Recycling
Catecholamine Biosynthetic Process
Regulation Of Synaptic Transmission, Dopaminergic
Response To Epinephrine
Regulation Of Dopamine Metabolic Process
Response To Bacterium
Response To Magnesium Ion
Phosphatidylethanolamine Acyl-chain Remodeling
Protein Modification By Small Protein Removal
Protein Deubiquitination
Regulation Of Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Catabolic Process
Proteolysis
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein K48-linked Deubiquitination
Cellular Metabolic Process
Monoubiquitinated Protein Deubiquitination
Dermatan Sulfate Biosynthetic Process
Regulation Of Phospholipase A2 Activity
Dermatan Sulfate Proteoglycan Biosynthetic Process
Dermatan Sulfate Proteoglycan Metabolic Process
Chondroitin Sulfate Catabolic Process
Protein K63-linked Deubiquitination
Histone Deubiquitination
Chondroitin Sulfate Biosynthetic Process
Metabolic Process
Chondroitin Sulfate Proteoglycan Biosynthetic Process
Regulation Of Protein Stability
Regulation Of Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Leukotriene Metabolic Process
Cellular Process
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Negative Regulation Of Cellular Protein Metabolic Process
Icosanoid Biosynthetic Process
Negative Regulation Of Arachidonic Acid Secretion
Lipoxin B4 Biosynthetic Process
Leukotriene A4 Metabolic Process
Cellular Response To DNA Damage Stimulus
Unsaturated Fatty Acid Biosynthetic Process
Proteoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Chondroitin Sulfate Metabolic Process
Negative Regulation Of Protein Metabolic Process
Tagcloud
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Difference)
?
1p35
adenomas
adenomatous
alleles
borderline
characterised
colonic
disequilibrium
duodenal
fap
genuine
inherited
locus
modifier
modify
mom1
noncoding
p36
phospholipase
pla2s
polymorphic
polyposis
polyps
secretory
silent
sporadic
syntenic
undetected
Tagcloud (Intersection)
?