USP47 and MED9

Number of citations of the paper that reports this interaction (PMID 14638676)
7

Data Source:
HPRD (in vitro)

		USP47	MED9
Gene Name		ubiquitin specific peptidase 47	mediator complex subunit 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm SCF Ubiquitin Ligase Complex	Mediator Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding WD40-repeat Domain Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Base-excision Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Growth Cellular Response To UV Monoubiquitinated Protein Deubiquitination Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AP4M1 MED29 MED9 PLA2G2A SNCA	26 interactors: APP CBX4 CDK8 MED1 MED11 MED12 MED13 MED14 MED16 MED18 MED19 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7 MED8 USP47
Entrez ID		55031	55090
HPRD ID		11668	14383
Ensembl ID		ENSG00000170242	ENSG00000141026
Uniprot IDs		Q96K76	Q9NWA0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Synaptic Vesicle Recycling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Phosphatidylinositol Acyl-chain Remodeling Regulation Of Neurotransmitter Uptake Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Negative Regulation Of Microtubule Polymerization Positive Regulation Of Neurotransmitter Secretion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Acyl-CoA Biosynthetic Process Cellular Response To Epinephrine Stimulus Golgi To Endosome Transport Positive Regulation Of Receptor Recycling Catecholamine Biosynthetic Process Regulation Of Synaptic Transmission, Dopaminergic Response To Epinephrine Regulation Of Dopamine Metabolic Process Response To Bacterium Response To Magnesium Ion Phosphatidylethanolamine Acyl-chain Remodeling	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Stem Cell Maintenance Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Stem Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Gene Expression Stem Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Differentiation Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Differentiation Cell Development Positive Regulation Of Metabolic Process Regulation Of Receptor Activity Cellular Process Developmental Growth Involved In Morphogenesis Negative Regulation Of Fibroblast Proliferation Axis Elongation Positive Regulation Of Receptor Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Thyroid Hormone Mediated Signaling Pathway
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