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PPP1CA and SFPQ
Number of citations of the paper that reports this interaction (PMID
21566083
)
2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, enzymatic study)
PPP1CA
SFPQ
Gene Name
protein phosphatase 1, catalytic subunit, alpha isozyme
splicing factor proline/glutamine-rich
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Protein Phosphatase Type 1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Glycogen Granule
Dendritic Spine
Perikaryon
Extracellular Vesicular Exosome
MLL5-L Complex
PTW/PP1 Phosphatase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Paraspeckles
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Phosphatase Activity
Ribonucleoprotein Complex Binding
Metal Ion Binding
Nucleotide Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Core Promoter Binding
Protein Binding
Histone Deacetylase Binding
Transcription Regulatory Region DNA Binding
Poly(A) RNA Binding
Biological Process
Glycogen Metabolic Process
Regulation Of Glycogen Biosynthetic Process
Regulation Of Glycogen Catabolic Process
Protein Dephosphorylation
Cell Cycle
Transforming Growth Factor Beta Receptor Signaling Pathway
Triglyceride Catabolic Process
Lung Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Small Molecule Metabolic Process
Branching Morphogenesis Of An Epithelial Tube
Cell Division
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Alternative MRNA Splicing, Via Spliceosome
DNA Repair
DNA Recombination
Transcription, DNA-templated
MRNA Processing
RNA Splicing
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Histone H3 Deacetylation
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Loss of Function of TGFBR2 in Cancer
Signaling by GPCR
TGFBR2 MSI Frameshift Mutants in Cancer
Metabolism of lipids and lipoproteins
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
Opioid Signalling
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Lipid digestion, mobilization, and transport
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
DARPP-32 events
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Endometrial cancer (
21499250
)
Protein-Protein Interactions
148 interactors:
AATK
AKAP1
AKAP11
AKAP9
AKT1
APAF1
AURKA
BAD
BAX
BCL2
BCL2L1
BCL2L2
BRCA1
BTBD10
C1QA
CAD
CASC5
CAV1
CCDC181
CD2BP2
CDC5L
CDH1
CEP170
CKB
CLCN2
CLTC
CNP
CNST
CNTN1
CREB1
CRK
CSNK1E
CSRNP1
CSRNP2
CUL1
CXXC1
DCTN1
DCX
DEAF1
EED
EIF2AK2
FRMPD4
FXYD1
GLIPR1L2
GLTSCR2
GPKOW
H2AFX
HEYL
HSPA4
IBTK
ID2
JPH3
KANK1
KCNQ1
KCTD20
KIAA1377
KIF13A
KIF18A
LMTK2
LPIN2
MAFG
MAL2
MAP4K4
MAPK1
MAPK3
MIIP
MPHOSPH10
MST1R
MYO16
NCAM1
NDP
NEK2
NOC2L
NOM1
NONO
PCDH7
PCNA
PHACTR1
PHACTR3
PHACTR4
PHC1
PIAS1
PIAS3
PLCL2
POLR2A
PPP1R10
PPP1R11
PPP1R13B
PPP1R13L
PPP1R15A
PPP1R15B
PPP1R16A
PPP1R18
PPP1R1B
PPP1R2
PPP1R26
PPP1R2P3
PPP1R2P9
PPP1R32
PPP1R37
PPP1R3B
PPP1R3C
PPP1R3D
PPP1R3E
PPP1R3G
PPP1R8
PPP1R9A
PPP1R9B
PPP2CA
PREX1
PRKCB
PRKCD
PRR16
PTEN
RANBP9
RB1
RIF1
RPRD2
SFPQ
SFRP1
SH3RF2
SKP1
SLC45A1
SNCAIP
SORL1
SPRED1
STAM
STAU1
SYTL2
TCTEX1D4
TOE1
TOR1AIP1
TOX4
TP53
TP53BP2
TPRN
TUSC3
UBE2Z
ULK1
VDR
WBP11
WDR82
WWTR1
YLPM1
ZBTB11
ZFYVE16
ZFYVE9
ZNF827
27 interactors:
APBB1
AR
CSNK2A1
ERG
EXOSC5
FHL2
FUS
GAS7
HIST3H3
HN1
NONO
PIN1
PPARG
PPP1CA
PRPF40A
PSPC1
PTBP1
RAC1
SIN3A
SMAD5
SNRPA
SREK1
TCERG1
TOP1
UBC
WBP4
ZMYM2
Entrez ID
5499
6421
HPRD ID
15942
07284
Ensembl ID
ENSG00000172531
ENSG00000116560
Uniprot IDs
P62136
P23246
Q86VG2
PDB IDs
3E7A
3E7B
3EGG
3EGH
3HVQ
3N5U
3V4Y
4G9J
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Regulation Of Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphatase Activity
Regulation Of Dephosphorylation
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Phosphatase Activity
Apoptotic Process
Negative Regulation Of Dephosphorylation
Regulation Of Cellular Component Organization
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Cellular Protein Metabolic Process
Cell Death
Negative Regulation Of Cellular Metabolic Process
Death
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Positive Regulation Of Protein Metabolic Process
Cell Cycle
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Cell Cycle Process
Regulation Of Phosphorylation
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Amino Acid Metabolic Process
Organelle Organization
Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Mitotic Cell Cycle Process
Regulation Of Organelle Organization
Cellular Response To Stress
Mitotic Cell Cycle
Positive Regulation Of Protein Modification Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Differentiation
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Protein Kinase Activity
Developmental Process
Positive Regulation Of Catalytic Activity
Multicellular Organismal Development
Anatomical Structure Development
Negative Regulation Of Kinase Activity
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Rhythmic Process
Regulation Of Circadian Rhythm
RNA Splicing
MRNA Metabolic Process
Transcription, DNA-templated
MRNA Processing
RNA Biosynthetic Process
Cellular Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
RNA Processing
Regulation Of Cell Death
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Circadian Rhythm
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Regulation Of Transcription, DNA-templated
Intracellular Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
DNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Cellular Component Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cell Cycle Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Biosynthetic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Tagcloud
?
0x
1x
adamts13
aspm
atp6v0a2
bioinformatic
bl
chickens
col12a1
fowl
grm5
interpretations
jungle
lrp2
obscn
plau
prkdc
resequencing
rnf168
sanger
sl
slv
smyth
stab2
ubc
ubiquitinylation
vitiliginous
vitiligo
xirp1
Tagcloud (Difference)
?
0x
1x
adamts13
aspm
atp6v0a2
bioinformatic
bl
chickens
col12a1
fowl
grm5
interpretations
jungle
lrp2
obscn
plau
prkdc
resequencing
rnf168
sanger
sl
slv
smyth
stab2
ubc
ubiquitinylation
vitiliginous
vitiligo
xirp1
Tagcloud (Intersection)
?