MPZ and PINX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MPZ	PINX1
Gene Name		myelin protein zero	PIN2/TERF1 interacting, telomerase inhibitor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Myelin Sheath	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Molecule Activity	Protein Binding Telomerase Inhibitor Activity Telomeric RNA Binding
	Biological Process	Synaptic Transmission Cell-cell Junction Maintenance	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity
Pathways
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)	Carotid intima media thickness ( 21909108) Retinal vascular caliber ( 21060863) Triglycerides ( 20686565)
Protein-Protein Interactions		3 interactors: PINX1 PMP22 PSMB3	10 interactors: AIDA CACYBP DHX15 GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63
Entrez ID		4359	54984
HPRD ID		01159	05934
Ensembl ID		ENSG00000158887	ENSG00000254093
Uniprot IDs		P25189	Q96BK5
PDB IDs		1N2P 3OAI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transferase Activity Bleb Assembly Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Metaphase Plate Congression Telomere Maintenance Via Telomere Lengthening Myelin Assembly Metaphase Plate Congression Establishment Of Chromosome Localization Cell Cycle Process Cell Death Death Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cell Cycle Positive Regulation Of Ligase Activity Telomere Maintenance Mitotic Sister Chromatid Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Segregation Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Proliferation Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint	Replicative Cell Aging Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Cell Aging Aging Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Chromatin Modification Telomere Maintenance Via Telomere Lengthening Chromatin Organization Ectoderm And Mesoderm Interaction Epidermal Cell Division Negative Regulation Of Production Of SiRNA Involved In RNA Interference Telomere Maintenance Chromosome Organization Negative Regulation Of RNA Interference Transcription, RNA-templated Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Telomeric Loop Formation Regulation Of Epidermal Cell Division Telomere Formation Via Telomerase Negative Regulation Of Mitotic Cell Cycle Phase Transition Female Genitalia Morphogenesis Negative Regulation Of Megakaryocyte Differentiation Cloacal Septation Urinary Bladder Development Mitotic Cell Cycle Checkpoint Developmental Process Regulation Of Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Negative Regulation Of Telomere Maintenance Via Telomerase Prostatic Bud Formation Regulation Of Cell Death Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Telomere Assembly Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Cell-cell Junction Maintenance Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Cell Cycle Phase Transition
Tagcloud ?		1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero	9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined
Tagcloud (Difference) ?		1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero	9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined
Tagcloud (Intersection) ?