MPZ and RGS4

		MPZ	RGS4
Description		myelin protein zero	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Myelin Sheath Synapse	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	Structural Molecule Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Chemical Synaptic Transmission Myelination Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral adipose tissue adjusted for BMI ( 22589738)	Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		3 interacting genes: PINX1 PMP22 PSMB3	15 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 PLCB1 PTAFR UBR1
Entrez ID		4359	5999
HPRD ID		01159	03947
Ensembl ID		ENSG00000158887	ENSG00000117152
Uniprot IDs		A0A5F9ZI26 P25189	P49798
PDB IDs		3OAI 8IIA
Enriched GO Terms of Interacting Partners?			Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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