GABPA and SP3

Number of citations of the paper that reports this interaction (PubMedID 11237613)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		GABPA	SP3
Description		GA binding protein transcription factor subunit alpha	Sp3 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytosol PML Body Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Ossification In Utero Embryonic Development Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Myeloid Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		Transcriptional activation of mitochondrial biogenesis	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 33627673) Gout (normal type) ( 32238385) Nicotine dependence symptom count ( 25555482)	Appendicular lean mass ( 33097823) End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		14 interacting genes: APP ATF1 CEBPA CREBBP EP300 GABPB1 HCFC1 MED1 OGT PINX1 SP1 SP3 STK16 ZC2HC1B	30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 MAP1LC3A NKX3-1 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 SUMO1 TP53 TP73 UBE2I VEGFA WHR1 ZBTB7A
Entrez ID		2551	6670
HPRD ID		11793	03483
Ensembl ID		ENSG00000154727	ENSG00000172845
Uniprot IDs		A8IE48 Q06546 Q8IYS3	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Protein Localization To Nucleus Transcription Coactivator Binding Regulation Of Glycolytic Process Chromatin Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Defense Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of ATP Metabolic Process STAT Family Protein Binding NSL Complex	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Chromatin Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Gene Expression Transcription Coregulator Binding DNA Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Gliogenesis Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Response To Oxygen Levels Histone Deacetylase Binding Nucleus Chromatin Organization Response To Stress Regulation Of Neurogenesis Cellular Response To Decreased Oxygen Levels DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Process
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