GABPA and ZC2HC1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GABPA	ZC2HC1B
Description		GA binding protein transcription factor subunit alpha	zinc finger C2HC-type containing 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 33627673) Gout (normal type) ( 32238385) Nicotine dependence symptom count ( 25555482)	Diffusing capacity of carbon monoxide ( 30694715)
Interacting Genes		14 interacting genes: APP ATF1 CEBPA CREBBP EP300 GABPB1 HCFC1 MED1 OGT PINX1 SP1 SP3 STK16 ZC2HC1B	6 interacting genes: CASTOR1 CFTR GABPA NCK2 NFKBID ZGPAT
Entrez ID		2551	153918
HPRD ID		11793	10178
Ensembl ID		ENSG00000154727	ENSG00000118491
Uniprot IDs		A8IE48 Q06546 Q8IYS3	Q5TFG8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Protein Localization To Nucleus Transcription Coactivator Binding Regulation Of Glycolytic Process Chromatin Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Defense Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of ATP Metabolic Process STAT Family Protein Binding NSL Complex	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Molecular Sensor Activity Cellular Response To L-arginine Bicarbonate Transmembrane Transporter Activity Response To Endoplasmic Reticulum Stress Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Amelogenesis Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Signal Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Activation Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity GATOR2 Complex Arginine Binding
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