ODAM and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		ODAM	TOLLIP
Description		odontogenic, ameloblast associated	toll interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cell Periphery Mitotic Spindle Supramolecular Fiber	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response Response To Wounding Positive Regulation Of Gene Expression Biomineral Tissue Development Regulation Of Actin Cytoskeleton Organization Odontogenesis Of Dentin-containing Tooth Positive Regulation Of GTPase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways		Amyloid fiber formation	Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS			Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		13 interacting genes: ADAM15 APP ARID5A HGS IKBKG MED25 POGZ SDCBP SNRPC SPATA31A7 TOLLIP VENTX YPEL3	78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19
Entrez ID		54959	54472
HPRD ID		13376	05887
Ensembl ID		ENSG00000109205	ENSG00000078902
Uniprot IDs		A1E959	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs			1WGL 2N31
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Nuclear Retinoid X Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Frizzled Binding Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of DNA-templated Transcription Interleukin-5 Receptor Complex Positive Regulation Of Mediator Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Regulation Of Primary Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To External Biotic Stimulus Protein Heterodimerization Activity Protein-containing Complex Assembly Lipoprotein Particle Regulation Of Receptor Internalization	NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding
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