ODAM and MED25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ODAM	MED25
Description		odontogenic, ameloblast associated	mediator complex subunit 25
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cell Periphery Mitotic Spindle Supramolecular Fiber	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding	Transcription Coactivator Binding Protein Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response Response To Wounding Positive Regulation Of Gene Expression Biomineral Tissue Development Regulation Of Actin Cytoskeleton Organization Odontogenesis Of Dentin-containing Tooth Positive Regulation Of GTPase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Mediator Complex Assembly
Pathways		Amyloid fiber formation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Blood trace element (Se levels) ( 23720494)
Interacting Genes		13 interacting genes: ADAM15 APP ARID5A HGS IKBKG MED25 POGZ SDCBP SNRPC SPATA31A7 TOLLIP VENTX YPEL3	38 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SENP3 SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		54959	81857
HPRD ID		13376	14380
Ensembl ID		ENSG00000109205	ENSG00000104973
Uniprot IDs		A1E959	M0QZQ2 Q71SY5
PDB IDs			2KY6 2L23 2L6U 2XNF 7EMF 7LBM 8GXQ 8GXS 8T9D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Nuclear Retinoid X Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Frizzled Binding Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of DNA-templated Transcription Interleukin-5 Receptor Complex Positive Regulation Of Mediator Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Regulation Of Primary Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To External Biotic Stimulus Protein Heterodimerization Activity Protein-containing Complex Assembly Lipoprotein Particle Regulation Of Receptor Internalization	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nuclear Receptor Activity Core Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Mediator Complex Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Coregulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Intracellular Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription
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