ODAM and ADAM15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ODAM	ADAM15
Description		odontogenic, ameloblast associated	ADAM metallopeptidase domain 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cell Periphery Mitotic Spindle Supramolecular Fiber	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cilium Cell Surface Endomembrane System Membrane Cytoplasmic Vesicle Motile Cilium Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Immunoglobulin Receptor Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Inflammatory Response Response To Wounding Positive Regulation Of Gene Expression Biomineral Tissue Development Regulation Of Actin Cytoskeleton Organization Odontogenesis Of Dentin-containing Tooth Positive Regulation Of GTPase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia
Pathways		Amyloid fiber formation	Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 34021172) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Walking pace ( 33128006)
Interacting Genes		13 interacting genes: ADAM15 APP ARID5A HGS IKBKG MED25 POGZ SDCBP SNRPC SPATA31A7 TOLLIP VENTX YPEL3	34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		54959	8751
HPRD ID		13376	05674
Ensembl ID		ENSG00000109205	ENSG00000143537
Uniprot IDs		A1E959	Q13444
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Nuclear Retinoid X Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Frizzled Binding Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of DNA-templated Transcription Interleukin-5 Receptor Complex Positive Regulation Of Mediator Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Immune Response Regulation Of Primary Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Early Endosome Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To External Biotic Stimulus Protein Heterodimerization Activity Protein-containing Complex Assembly Lipoprotein Particle Regulation Of Receptor Internalization	Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Regulation Of Cellular Component Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Biogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Tyrosine Kinase Activity Cytosol Positive Regulation Of Lymphocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Positive Regulation Of Organelle Organization Positive Regulation Of T Cell Activation Regulation Of MAPK Cascade Peptidyl-tyrosine Phosphorylation Regulation Of Lymphocyte Activation Positive Regulation Of Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell-cell Adhesion Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Immune Response
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