UBA3 and DSCAM

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		UBA3	DSCAM
Description		ubiquitin like modifier activating enzyme 3	DS cell adhesion molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding
	Biological Process	Mitotic Cell Cycle Proteolysis Endomitotic Cell Cycle Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Cell Cycle	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance
Pathways		Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	DSCAM interactions DSCAM interactions
Drugs
Diseases
GWAS		Meat-related diet ( 32066663)	Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		16 interacting genes: CHD3 CPNE2 CUL5 DSCAM DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT RNF7 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M	157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365
Entrez ID		9039	1826
HPRD ID		04413	03953
Ensembl ID		ENSG00000144744	ENSG00000171587
Uniprot IDs		F8W8D4 Q8TBC4	O60469
PDB IDs		1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM	6ZR7
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation NEDD8 Transferase Activity Protein Modification Process Post-translational Protein Modification Regulation Of Cell Junction Assembly NEDD8 Conjugating Enzyme Activity Negative Regulation Of Focal Adhesion Disassembly NEDD8 Ligase Activity Protein Metabolic Process Regulation Of Postsynapse Assembly Protein Ubiquitination Regulation Of Synapse Assembly Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Epithelial To Mesenchymal Transition Ubiquitin-protein Transferase Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Layer Formation In Cerebral Cortex Mesenchymal Cell Differentiation Negative Regulation Of Focal Adhesion Assembly Regulation Of Synapse Organization Innate Immune Response Growth Hormone Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Postsynapse Organization Proteolysis Involved In Protein Catabolic Process CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Nucleus Defense Response To Symbiont Proteolysis Transferase Activity Defense Response To Other Organism Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Regulation Of Cellular Component Organization Macromolecule Metabolic Process Regulation Of Neuron Migration Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response Regulation Of Glycolytic Process	Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding
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