UBA3 and IMPA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		UBA3	IMPA2
Description		ubiquitin like modifier activating enzyme 3	inositol monophosphatase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Glucose-1-phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Metal Ion Binding Glycerol-2-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity
	Biological Process	Mitotic Cell Cycle Proteolysis Endomitotic Cell Cycle Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Cell Cycle	Inositol Metabolic Process Inositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Response To Lithium Ion Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			Lithium cation Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		Meat-related diet ( 32066663)	Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Hemoglobin ( 32888494) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Stroke ( 17434096)
Interacting Genes		16 interacting genes: CHD3 CPNE2 CUL5 DSCAM DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT RNF7 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M	5 interacting genes: CCT6A HERPUD1 SLC44A3 TNFRSF14 UBA3
Entrez ID		9039	3613
HPRD ID		04413	09329
Ensembl ID		ENSG00000144744	ENSG00000141401
Uniprot IDs		F8W8D4 Q8TBC4	O14732
PDB IDs		1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM	2CZH 2CZI 2CZK 2DDK 2FVZ
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation NEDD8 Transferase Activity Protein Modification Process Post-translational Protein Modification Regulation Of Cell Junction Assembly NEDD8 Conjugating Enzyme Activity Negative Regulation Of Focal Adhesion Disassembly NEDD8 Ligase Activity Protein Metabolic Process Regulation Of Postsynapse Assembly Protein Ubiquitination Regulation Of Synapse Assembly Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Epithelial To Mesenchymal Transition Ubiquitin-protein Transferase Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Layer Formation In Cerebral Cortex Mesenchymal Cell Differentiation Negative Regulation Of Focal Adhesion Assembly Regulation Of Synapse Organization Innate Immune Response Growth Hormone Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Postsynapse Organization Proteolysis Involved In Protein Catabolic Process CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Nucleus Defense Response To Symbiont Proteolysis Transferase Activity Defense Response To Other Organism Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Regulation Of Cellular Component Organization Macromolecule Metabolic Process Regulation Of Neuron Migration Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response Regulation Of Glycolytic Process	Positive Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Adaptive Immune Memory Response Endomitotic Cell Cycle NEDD8 Activating Enzyme Activity Lewy Body Core
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