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UBA3 and UBE2F
Number of citations of the paper that reports this interaction (PMID
19250909
)
47
Data Source:
BioGRID
(enzymatic study)
UBA3
UBE2F
Gene Name
ubiquitin-like modifier activating enzyme 3
ubiquitin-conjugating enzyme E2F (putative)
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Cytoplasm
Molecular Function
Protein Binding
ATP Binding
Acid-amino Acid Ligase Activity
NEDD8 Activating Enzyme Activity
Protein Heterodimerization Activity
Protein Binding
ATP Binding
Ligase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Cellular Protein Modification Process
Proteolysis
Endomitotic Cell Cycle
Protein Neddylation
Regulation Of Cell Cycle
Protein Ubiquitination
Protein Neddylation
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
CHD3
CPNE2
IMPA2
KDM1A
NAE1
NEDD8
UBC
UBE2F
UBE2M
9 interactors:
CUL1
CUL5
DCUN1D1
DCUN1D2
NAE1
NEDD8
RNF34
RNF7
UBA3
Entrez ID
9039
140739
HPRD ID
04413
14812
Ensembl ID
ENSG00000144744
ENSG00000184182
Uniprot IDs
B7Z5F6
Q8TBC4
C9J212
H9KVB9
Q969M7
PDB IDs
1R4M
1R4N
1TT5
1Y8X
1YOV
2LQ7
2NVU
3DBH
3DBL
3DBR
3FN1
3GZN
2EDI
3FN1
4GBA
Enriched GO Terms of Interacting Partners
?
Protein Neddylation
Protein Modification By Small Protein Conjugation
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Protein Modification Process
Regulation Of Primitive Erythrocyte Differentiation
Mitotic DNA Integrity Checkpoint
Cellular Response To Growth Factor Stimulus
Cellular Protein Metabolic Process
Regulation Of Apoptotic Process
Response To Growth Factor
Regulation Of Cell Death
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Carbohydrate Biosynthetic Process
Cellular Metabolic Process
Mitotic Cell Cycle Checkpoint
Mitotic DNA Replication Checkpoint
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Histone H3-K4 Methylation
Histone H3-K9 Demethylation
Histone H3-K4 Demethylation
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Cellular Carbohydrate Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Neuron Apoptotic Process
Inositol Biosynthetic Process
Protein Metabolic Process
Positive Regulation Of Megakaryocyte Differentiation
DNA Replication Checkpoint
Viral Protein Processing
Cell Cycle Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Inositol Phosphate Dephosphorylation
Positive Regulation Of Hormone Biosynthetic Process
Regulation Of Neuron Death
Negative Regulation Of Histone H3-K9 Methylation
Phosphorylated Carbohydrate Dephosphorylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Granulocyte Differentiation
Regulation Of Megakaryocyte Differentiation
Protein Neddylation
Protein Modification By Small Protein Conjugation
Apoptotic Process
Cellular Protein Modification Process
Programmed Cell Death
Cell Death
Death
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Protein Catabolic Process
Cellular Protein Metabolic Process
Proteolysis
Mitotic Cell Cycle
Cellular Macromolecule Catabolic Process
Regulation Of Cell Cycle
Apoptotic Signaling Pathway
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Cell Cycle
Regulation Of Oxygen Metabolic Process
Endomitotic Cell Cycle
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Cell Cycle Arrest
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Cold
Mitotic DNA Replication Checkpoint
Catabolic Process
Signal Transduction
Negative Regulation Of Execution Phase Of Apoptosis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Signaling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Communication
DNA Replication Checkpoint
Cell Cycle Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Response To Redox State
Cellular Response To Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Execution Phase Of Apoptosis
Tagcloud
?
activase
activases
conjugases
developmentally
discreet
dysregulated
e1
e3
homeostatic
k48
k63
ligases
mount
nedd
nedd8ylation
pias3
polyubiquitination
postmortem
rnf7
schizophrenia
sinai
stg
sumoylation
ubiquitination
ubl
ufl1
ufmylation
underlies
Tagcloud (Difference)
?
activase
activases
conjugases
developmentally
discreet
dysregulated
e1
e3
homeostatic
k48
k63
ligases
mount
nedd
nedd8ylation
pias3
polyubiquitination
postmortem
rnf7
schizophrenia
sinai
stg
sumoylation
ubiquitination
ubl
ufl1
ufmylation
underlies
Tagcloud (Intersection)
?