BCOR and HDAC5

Number of citations of the paper that reports this interaction (PMID 10898795)
55

Data Source:
HPRD (in vivo)

		BCOR	HDAC5
Gene Name		BCL6 corepressor	histone deacetylase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus PcG Protein Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Heat Shock Protein Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K36 Methylation Transcription, DNA-templated Heart Development Negative Regulation Of Bone Mineralization Histone H2A Monoubiquitination Odontogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K4 Methylation Palate Development Specification Of Axis Polarity Negative Regulation Of Tooth Mineralization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Pit-and-Fissure caries ( 23470693)	Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		17 interactors: BCL6 CPNE1 CPNE2 CPNE4 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 MLLT3 NAA10 NACC1 PCGF3 PCGF5 SP1 UBTD1 USP7	59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		54880	10014
HPRD ID		06458	09246
Ensembl ID		ENSG00000183337	ENSG00000108840
Uniprot IDs		Q6W2J9	Q9UQL6
PDB IDs		3BIM 4HPL
Enriched GO Terms of Interacting Partners?		Histone H4 Deacetylation Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Protein Deacetylation Transcription, DNA-templated RNA Biosynthetic Process Histone Modification RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Modification Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Peptidyl-lysine Deacetylation Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Myotube Differentiation B Cell Differentiation Regulation Of Receptor Biosynthetic Process Regulation Of Skeletal Muscle Fiber Development Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway Notch Signaling Pathway Negative Regulation Of Cellular Metabolic Process B Cell Activation Osteoblast Development Positive Regulation Of Macromolecule Biosynthetic Process Organelle Organization Cellular Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation
Tagcloud ?		aa acquisition aging asxl1 attrition bonafide clonal context critically dnmt3a dysregulation especially evolution exome explored haemopoiesis hierarchical infancy nearly points predicting regulators replicative sampling sequencing serial still telomere unbiased	125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis
Tagcloud (Difference) ?		aa acquisition aging asxl1 attrition bonafide clonal context critically dnmt3a dysregulation especially evolution exome explored haemopoiesis hierarchical infancy nearly points predicting regulators replicative sampling sequencing serial still telomere unbiased	125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis
Tagcloud (Intersection) ?