BCOR and MLLT3

Number of citations of the paper that reports this interaction (PubMedID 12776190)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		BCOR	MLLT3
Description		BCL6 corepressor	MLLT3 super elongation complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm BCOR Complex	Nucleus Nucleoplasm Chromosome Cytosol Transcription Elongation Factor Complex Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Heat Shock Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	DNA Binding Chromatin Binding Protein Binding Histone Binding Molecular Adaptor Activity Modification-dependent Protein Binding Histone H3K18ac Reader Activity Histone H3K9ac Reader Activity Histone H3K27ac Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Heart Development Negative Regulation Of Bone Mineralization Odontogenesis Negative Regulation Of DNA-templated Transcription Roof Of Mouth Development Specification Of Axis Polarity Negative Regulation Of Tooth Mineralization	Chromatin Organization Segment Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of DNA-templated Transcription Hematopoietic Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chromatin Organization Regulation Of Stem Cell Division Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Pit-and-Fissure caries ( 23470693) Platelet count ( 29403010) Refractive error ( 32231278) Venous thromboembolism ( 31676865)	Atrial fibrillation ( 29892015) Dietary fat liking ( 32516399) Estimated glomerular filtration rate ( 31152163) Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Platelet distribution width ( 32888494) Response to montelukast in asthma (change in FEV1) ( 26083242) Systolic blood pressure ( 30578418)
Interacting Genes		16 interacting genes: BCL6 CPNE1 CPNE2 CPNE4 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 MLLT3 NAA10 NACC1 SP1 UBTD1 USP7 ZBTB5	18 interacting genes: AFF1 ALKBH4 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 H3C1 LRIF1 LRRK2 MCM6 NRIP1 PTN RBM48 SGK1 VAX1 ZNF572
Entrez ID		54880	4300
HPRD ID		06458	01163
Ensembl ID		ENSG00000183337	ENSG00000171843
Uniprot IDs		H7BZ37 H7C231 Q6W2J9	A0A0S2Z448 P42568
PDB IDs		2N1L 3BIM 4HPL 6B7G 8HCU	2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6L5Z 6LS6 6MIL 6MIM 7EIC 7EID 7VKG 7VKH 8PJ7 8TLV 8TLW 8TLX 9ARO 9ARR
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Histone Deacetylase Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Complex Protein Deacetylation Transcription Corepressor Binding Negative Regulation Of Myotube Differentiation Epigenetic Regulation Of Gene Expression Macromolecule Deacylation Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Chromatin Organization Transcription Repressor Complex DNA-binding Transcription Factor Binding Negative Regulation Of Muscle Cell Differentiation Chromatin Remodeling Regulation Of Striated Muscle Cell Differentiation Protein Lysine Delactylase Activity Negative Regulation Of Gene Expression NF-kappaB Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Muscle Cell Differentiation Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Deacetylase Activity Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Calcium Ion Nucleus Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Rhythmic Process Transcription Cis-regulatory Region Binding	Cell Projection Morphogenesis Golgi-associated Vesicle Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Neuron Projection Morphogenesis Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Regulation Of Metabolic Process Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Nucleoplasm Regulation Of Neuroblast Proliferation Neuron Projection Arborization Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Neuroblast Proliferation Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Memory Molecular Function Activator Activity Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Metabolic Process Dendrite Development Cyclin D2-CDK6 Complex Response To Polyamine Macromolecule Response To Reactive Oxygen Species Ovarian Follicle Rupture DNA N6-methyladenine Demethylase Activity Negative Regulation Of Tooth Mineralization BCOR Complex
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