ZCCHC2 and ERCC1

Data Source: HiPPIP (Novel)

		ZCCHC2	ERCC1
Name		zinc finger CCHC-type containing 2	ERCC excision repair 1, endonuclease non-catalytic subunit
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex
	Molecular Function	Nucleic Acid Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	None	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		None	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Diseases		None	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		A body shape index ( 34021172 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Bipolar disorder ( 31043756 33263727 ) Breastfeeding duration ( 25475840 ) Chronotype ( 30696823 ) Cognitive function in longevity ( 33607172 ) Menopause (age at onset) ( 29773799 ) Morning person ( 30696823 ) Pulse pressure ( 30224653 ) Serum albumin levels ( 23022100 ) Waist circumference adjusted for body mass index ( 34021172 )	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Simvastatin-induced myopathy ( 31220337 )
Novel Interactors		7 novel interactors: ERCC1 HMSD MDM4 PHLPP1 PIGN RELCH SERPINB7	1 novel interactors: ZCCHC2
Interacting Genes		2 interacting genes: RNF10 SHANK3	19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA
Entrez ID		54877	2067
HPRD ID		11696	00533
Ensembl ID		ENSG00000141664	ENSG00000012061
Uniprot IDs		Q9BRD4 Q9C0B9	P07992
PDB IDs		Not available	1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
GO Terms Enriched among Interactors		None	Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening