ZCCHC2 and PHLPP1

Data Source: HiPPIP (Novel)

		ZCCHC2	PHLPP1
Name		zinc finger CCHC-type containing 2	PH domain and leucine rich repeat protein phosphatase 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	None	Regulation Of T Cell Anergy Apoptotic Process Entrainment Of Circadian Clock Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of P38MAPK Cascade
Pathways		None	Negative regulation of the PI3K/AKT network
GWAS		A body shape index ( 34021172 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Bipolar disorder ( 31043756 33263727 ) Breastfeeding duration ( 25475840 ) Chronotype ( 30696823 ) Cognitive function in longevity ( 33607172 ) Menopause (age at onset) ( 29773799 ) Morning person ( 30696823 ) Pulse pressure ( 30224653 ) Serum albumin levels ( 23022100 ) Waist circumference adjusted for body mass index ( 34021172 )	Aggressiveness in attention deficit hyperactivity disorder ( 27021288 ) Hip circumference adjusted for BMI ( 28552196 ) Plateletcrit ( 32888494 )
Novel Interactors		7 novel interactors: ERCC1 HMSD MDM4 PHLPP1 PIGN RELCH SERPINB7	2 novel interactors: SERPINB7 ZCCHC2
Interacting Genes		2 interacting genes: RNF10 SHANK3	6 interacting genes: BRAP CSNK1A1 GSK3B NHERF1 TRIM11 WDR48
Entrez ID		54877	23239
HPRD ID		11696	15145
Ensembl ID		ENSG00000141664	ENSG00000081913
Uniprot IDs		Q9BRD4 Q9C0B9	O60346
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Negative Regulation Of Protein-containing Complex Assembly Maintenance Of Cell Polarity Negative Regulation Of Wnt Signaling Pathway Viral Protein Processing Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of TOR Signaling TOR Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein-containing Complex Assembly Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Establishment Of Cell Polarity Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Platelet-derived Growth Factor Production Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Negative Regulation Of AIM2 Inflammasome Complex Assembly Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Platelet-derived Growth Factor Production Type 3 Metabotropic Glutamate Receptor Binding Regulation Of TOR Signaling Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Protein Modification Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity