PIGG and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		PIGG	GLP1R
Gene Name		phosphatidylinositol glycan anchor biosynthesis, class G	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphotransferase Activity, For Other Substituted Phosphate Groups CP2 Mannose-ethanolamine Phosphotransferase Activity	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Post-translational Protein Modification Cellular Protein Metabolic Process	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Synthesis of glycosylphosphatidylinositol (GPI) Post-translational protein modification Post-translational modification: synthesis of GPI-anchored proteins	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP GLP1R PIGF	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		54872	2740
HPRD ID		07890	00677
Ensembl ID		ENSG00000174227	ENSG00000112164
Uniprot IDs		E7EWV1 Q5H8A4 Q8NCI4	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Learning Or Memory Cognition Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Single-organism Behavior Neuron Remodeling Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Preassembly Of GPI Anchor In ER Membrane Behavior Cellular Copper Ion Homeostasis Cellular Homeostasis CAMP-mediated Signaling Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle C-terminal Protein Lipidation Activation Of Adenylate Cyclase Activity Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cyclic-nucleotide-mediated Signaling Chemical Homeostasis Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Adenylate Cyclase Activity RNA Polyadenylation Neuron Recognition Cellular Response To Glucagon Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Lyase Activity Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Response To Glucagon Positive Regulation Of Mitotic Cell Cycle Phase Transition Neurological System Process	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		able aigf analog antigenic antigenicity capable degree enzymic exist existence homologies homology inhibit insulin kinase mediator nevertheless peculiar phosphorylating polyclonal polypeptide possess pronounced revealing specificities substrates technology tyrosine	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		able aigf analog antigenic antigenicity capable degree enzymic exist existence homologies homology inhibit insulin kinase mediator nevertheless peculiar phosphorylating polyclonal polypeptide possess pronounced revealing specificities substrates technology tyrosine	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?