CALCOCO1 and ARNT

Number of citations of the paper that reports this interaction (PubMedID 19324882)
49

Data Source:
BioGRID (x-ray crystallography, pull down)

		CALCOCO1	ARNT
Description		calcium binding and coiled-coil domain 1	aryl hydrocarbon receptor nuclear translocator
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body Aryl Hydrocarbon Receptor Complex Nuclear Aryl Hydrocarbon Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Positive Regulation Of Gene Expression Wnt Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Inflammatory Response Intestinal Epithelial Structure Maintenance
Pathways			Regulation of gene expression by Hypoxia-inducible Factor PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Panic disorder ( 19165232) Toenail selenium levels ( 25343990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 21983785 28212542) Metabolic syndrome ( 31589552) Platelet count ( 32888494) Rhegmatogenous retinal detachment ( 23585552) Tea consumption ( 31046077) Urate levels ( 23263486)
Interacting Genes		37 interacting genes: APP APTX ARNT BFSP2 CEP19 CREBBP CRYBA2 CTNNBL1 CWF19L2 CYTH3 DUSP13B ENKD1 EP300 FAM161A FOSL1 FXR1 GABARAPL1 GABARAPL2 GRIK2 IPP ISOC1 KRT15 MAPK1 MYH6 NDC80 NEDD4 PCBD1 POLR2A PRKAA2 RNF8 SH3GL3 SHANK3 SMURF1 SRPK2 TBC1D15 TBC1D17 ZMAT2	78 interacting genes: ADH5 AHR AHRR AIP AKT1 ARL14 ARNT2 BECN1 BRCA1 CALCOCO1 CASP3 CASP9 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLOCK CSNK2A1 DIABLO EP300 EPAS1 EPHA2 ERBB2 ESR1 FGFR4 FZR1 GLIS1 GLIS2 GMNN GTF2F1 GTF2F2 HEY1 HEY2 HGF HIF1A HIF3A HNF4A IRAK4 KPNA1 KPNA3 KPNA5 KPNA6 LATS2 LSM8 MAP2K5 MAPK14 MTA3 MYC NCOA1 NCOA2 NCOA7 NCOR2 NF2 NPAS2 NPAS4 PDGFRA PML PTGES3 RAF1 RELA SENP6 SIM1 SIM2 SMAD9 SP1 STK11 STRBP TACC3 TEAD2 TGM2 TNFAIP1 TRIP11 TUBB2A UBE2I
Entrez ID		57658	405
HPRD ID		13868	00524
Ensembl ID		ENSG00000012822	ENSG00000143437
Uniprot IDs		Q9P1Z2	A8K6P0 B0AZM1 P27540 Q53F30
PDB IDs			1X0O 2A24 2B02 2HV1 2K7S 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP 5V0L 6CZW 6D09 6D0B 6D0C 6X21 6X28 6X2H 6X37 6X3D 8CK3 8CK4 8CK8 8G4A 8XS6 8XS7 8XS8 8XS9 8XSA 8XSB
Enriched GO Terms of Interacting Partners?		Cytoplasm Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Regulation Of Glycolytic Process Histone H3K27 Acetyltransferase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Glycolytic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Cellular Response To Nutrient Levels Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Nucleoplasm Intracellular Signal Transduction Ciliary Basal Body Positive Regulation Of ATP Metabolic Process Regulation Of Synaptic Plasticity Regulation Of Tubulin Deacetylation Regulation Of Long-term Synaptic Potentiation Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nitrogen Starvation Regulation Of Protein Deacetylation Positive Regulation Of Synaptic Transmission Negative Regulation Of Long-term Synaptic Potentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Stress Peptidyl-lysine Acetylation Intracellular Signaling Cassette Positive Regulation Of Small Molecule Metabolic Process Cytosol Damaged DNA Binding Prp19 Complex Phosphatidylethanolamine Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Heat Ubiquitin Protein Ligase Binding Regulation Of Cell Projection Organization Chromatin Binding Organelle Organization Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Response To Nutrient Levels GABA Receptor Binding Regulation Of Small Molecule Metabolic Process Cellular Response To Starvation	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of Gene Expression Rhythmic Process Developmental Process Cytoplasm Cell Differentiation Regulation Of Cell Cycle Signal Transduction Animal Organ Development Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation DNA-templated Transcription Regulation Of Programmed Cell Death DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cytosol DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Developmental Process
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