PDHA1

Description		pyruvate dehydrogenase E1 subunit alpha 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Catalytic Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CFTR DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5160
HPRD ID		02420
Ensembl ID		ENSG00000131828
Uniprot IDs		P08559
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?		Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Fatty Acid Metabolic Process Regulation Of Ketone Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Glucose Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Monosaccharide Metabolic Process Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of PH Acetyl-CoA Biosynthetic Process Carbohydrate Metabolic Process Protein Kinase Activity Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Kinase Activity Cellular Response To Fatty Acid Regulation Of Fatty Acid Biosynthetic Process ATP Binding Small Molecule Metabolic Process Response To Fatty Acid Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Assembly Of Large Subunit Precursor Of Preribosome Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Pyruvate Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Insulin Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Anion Channel Activity Dihydrolipoyllysine-residue Acetyltransferase Activity Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Monoatomic Cation Homeostasis Positive Regulation Of Monoatomic Anion Transport Cellular Response To Lipid Pyruvate Dehydrogenase (acetyl-transferring) Activity Monoatomic Ion Homeostasis
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