PDHA1 and PDP1

Number of citations of the paper that reports this interaction (PubMedID 7782287)
0

Data Source:
HPRD (in vitro)

		PDHA1	PDP1
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase phosphatase catalytic subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Catalytic Complex	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex
Drugs		NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CFTR DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	11 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 OGT PDHA1 PRKCD SIRT3
Entrez ID		5160	54704
HPRD ID		02420	16185
Ensembl ID		ENSG00000131828	ENSG00000164951
Uniprot IDs		P08559	Q6P1N1 Q9P0J1
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?		Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Fatty Acid Metabolic Process Regulation Of Ketone Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Glucose Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Monosaccharide Metabolic Process Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of PH Acetyl-CoA Biosynthetic Process Carbohydrate Metabolic Process Protein Kinase Activity Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Kinase Activity Cellular Response To Fatty Acid Regulation Of Fatty Acid Biosynthetic Process ATP Binding Small Molecule Metabolic Process Response To Fatty Acid Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Assembly Of Large Subunit Precursor Of Preribosome Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Pyruvate Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Insulin Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Anion Channel Activity Dihydrolipoyllysine-residue Acetyltransferase Activity Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Monoatomic Cation Homeostasis Positive Regulation Of Monoatomic Anion Transport Cellular Response To Lipid Pyruvate Dehydrogenase (acetyl-transferring) Activity Monoatomic Ion Homeostasis	Positive Regulation Of Ceramide Biosynthetic Process Acetyl-CoA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Salivary Gland Morphogenesis Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Positive Regulation Of Lipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Regulation Of Membrane Lipid Metabolic Process Positive Regulation Of Lipid Metabolic Process Enzyme Binding Acetyl-CoA Metabolic Process Gland Morphogenesis Positive Regulation Of Amide Metabolic Process Regulation Of Lipid Biosynthetic Process Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metanephric Proximal Convoluted Tubule Development Epithelium Development Propionyl-CoA Biosynthetic Process Transferase Activity C-acetyltransferase Activity Positive Regulation Of Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Signaling Multivesicular Body, Internal Vesicle Lumen Regulation Of Catalytic Activity Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of DNA Metabolic Process Tissue Development Kidney Epithelium Development Positive Regulation Of Phosphate Metabolic Process Shc-EGFR Complex Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Regulation Of Lateral Mesodermal Cell Fate Specification Regulation Of Lipid Metabolic Process Regulation Of Amide Metabolic Process Positive Regulation Of Sphingomyelin Catabolic Process
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