PDHA1 and PDHB

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, biochemical, biochemical)
HPRD (in vivo)

		PDHA1	PDHB
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase E1 subunit beta
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Catalytic Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Purine-containing Compound Biosynthetic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		NADH	Pyruvic acid NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Apolipoprotein B levels ( 32203549) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		9 interacting genes: CFTR DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	18 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RBM11 RCC1 TRIM63 TSC22D1
Entrez ID		5160	5162
HPRD ID		02420	01530
Ensembl ID		ENSG00000131828	ENSG00000168291
Uniprot IDs		P08559	A0A384MDR8 P11177
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?		Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Fatty Acid Metabolic Process Regulation Of Ketone Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Glucose Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Monosaccharide Metabolic Process Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of PH Acetyl-CoA Biosynthetic Process Carbohydrate Metabolic Process Protein Kinase Activity Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Kinase Activity Cellular Response To Fatty Acid Regulation Of Fatty Acid Biosynthetic Process ATP Binding Small Molecule Metabolic Process Response To Fatty Acid Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Assembly Of Large Subunit Precursor Of Preribosome Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Pyruvate Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Insulin Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Anion Channel Activity Dihydrolipoyllysine-residue Acetyltransferase Activity Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Monoatomic Cation Homeostasis Positive Regulation Of Monoatomic Anion Transport Cellular Response To Lipid Pyruvate Dehydrogenase (acetyl-transferring) Activity Monoatomic Ion Homeostasis	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Acetyl-CoA Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Protein-containing Complex Binding Pyruvate Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Migration Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Positive Regulation Of Amino Acid Transport Cell Migration Involved In Sprouting Angiogenesis Glucose Metabolic Process Cellular Response To Low-density Lipoprotein Particle Stimulus Tricarboxylic Acid Cycle Amide Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Regulation Of Fibroblast Migration Carboxylic Acid Metabolic Process TRNA Methylation Organic Acid Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Blood Vessel Endothelial Cell Migration Regulation Of TRNA Methylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition High-affinity IgE Receptor Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Myoblast Fate Specification Integrin Alpha7-beta1 Complex Cellular Defense Response Protein Kinase Binding Monocarboxylic Acid Metabolic Process Excitatory Postsynaptic Potential Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Localization To Lysosome PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Type I Hypersensitivity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
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