PDHA1 and PDK1

Number of citations of the paper that reports this interaction (PubMedID 11485553)
26

Data Source:
HPRD (in vitro)

		PDHA1	PDK1
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Catalytic Complex	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle	Glucose Metabolic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Cellular Response To Stress Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation
Drugs		NADH	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		9 interacting genes: CFTR DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	16 interacting genes: AKT1 BIN1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ
Entrez ID		5160	5163
HPRD ID		02420	03954
Ensembl ID		ENSG00000131828	ENSG00000152256
Uniprot IDs		P08559	B7Z207 B7Z7N6 Q15118
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?		Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Fatty Acid Metabolic Process Regulation Of Ketone Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Glucose Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Monosaccharide Metabolic Process Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of PH Acetyl-CoA Biosynthetic Process Carbohydrate Metabolic Process Protein Kinase Activity Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Kinase Activity Cellular Response To Fatty Acid Regulation Of Fatty Acid Biosynthetic Process ATP Binding Small Molecule Metabolic Process Response To Fatty Acid Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Assembly Of Large Subunit Precursor Of Preribosome Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Pyruvate Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Insulin Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Anion Channel Activity Dihydrolipoyllysine-residue Acetyltransferase Activity Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Monoatomic Cation Homeostasis Positive Regulation Of Monoatomic Anion Transport Cellular Response To Lipid Pyruvate Dehydrogenase (acetyl-transferring) Activity Monoatomic Ion Homeostasis	Glucose Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Positive Regulation Of TOR Signaling Insulin Receptor Signaling Pathway Pyruvate Dehydrogenase Complex Carbohydrate Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus TOR Signaling Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of TORC1 Signaling Cellular Response To Insulin Stimulus Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Programmed Cell Death Tricarboxylic Acid Cycle Cellular Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Protein-containing Complex Cellular Response To Nutrient Response To Peptide Hormone Cellular Response To Oxygen-containing Compound Transferase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Translational Initiation Response To Hormone Phosphate-containing Compound Metabolic Process Response To Insulin Kinase Activity Pyruvate Decarboxylation To Acetyl-CoA ATP Binding Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction Pyruvate Metabolic Process Regulation Of Biological Quality Organic Acid Metabolic Process Response To Ketone Anoikis Positive Regulation Of Intracellular Signal Transduction Response To Activity Positive Regulation Of Signal Transduction
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