PDHA1 and PDK1

Number of citations of the paper that reports this interaction (PMID 12676647)
68

Data Source:
HPRD (in vitro)

		PDHA1	PDK1
Gene Name		pyruvate dehydrogenase (lipoamide) alpha 1	pyruvate dehydrogenase kinase, isozyme 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Glycolytic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH
Diseases
GWAS			Erectile dysfunction ( 22704111)
Protein-Protein Interactions		8 interactors: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	9 interactors: DLAT KAT2B PDHA1 PDK2 RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		5160	5163
HPRD ID		02420	03954
Ensembl ID		ENSG00000131828
Uniprot IDs		P08559	B7Z937 E9PD65 Q15118
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Insulin Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cellular Response To Oxygen Levels Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Response To Hormone Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration Cellular Response To Acid Chemical Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Metabolic Process Hexose Metabolic Process Cellular Response To Insulin Stimulus Monosaccharide Metabolic Process Tricarboxylic Acid Cycle Regulation Of Gluconeogenesis Long-term Memory Citrate Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Peptide Aerobic Respiration Apoptotic Process Programmed Cell Death Cell Death Death Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Glucose Metabolic Process Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Positive Regulation Of Skeletal Muscle Tissue Growth Memory Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Cellular Hyperosmotic Salinity Response Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation N-terminal Peptidyl-lysine Acetylation Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Renal Sodium Ion Absorption Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Respiration Renal Sodium Ion Transport Skeletal Muscle Atrophy Regulation Of Cellular Process Cellular Response To X-ray Striated Muscle Atrophy Response To Leucine Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh	additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine
Tagcloud (Difference) ?		coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh	additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine
Tagcloud (Intersection) ?