PDHA1 and PDK3

Number of citations of the paper that reports this interaction (PubMedID 11485553)
26

Data Source:
HPRD (in vitro)

		PDHA1	PDK3
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehydrogenase kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Catalytic Complex	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Cellular Response To Stress Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH	Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Malaria ( 31844061)
Interacting Genes		9 interacting genes: CFTR DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	4 interacting genes: APP DLAT EGFR PDHA1
Entrez ID		5160	5165
HPRD ID		02420	03956
Ensembl ID		ENSG00000131828	ENSG00000067992
Uniprot IDs		P08559	Q15120
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?		Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Fatty Acid Metabolic Process Regulation Of Ketone Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Glucose Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Monosaccharide Metabolic Process Mitochondrion Pyruvate Decarboxylation To Acetyl-CoA Regulation Of PH Acetyl-CoA Biosynthetic Process Carbohydrate Metabolic Process Protein Kinase Activity Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Kinase Activity Cellular Response To Fatty Acid Regulation Of Fatty Acid Biosynthetic Process ATP Binding Small Molecule Metabolic Process Response To Fatty Acid Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Assembly Of Large Subunit Precursor Of Preribosome Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Pyruvate Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Insulin Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Anion Channel Activity Dihydrolipoyllysine-residue Acetyltransferase Activity Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Monoatomic Cation Homeostasis Positive Regulation Of Monoatomic Anion Transport Cellular Response To Lipid Pyruvate Dehydrogenase (acetyl-transferring) Activity Monoatomic Ion Homeostasis	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Pyruvate Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Sulfur Compound Biosynthetic Process Acyl-CoA Metabolic Process Multivesicular Body, Internal Vesicle Lumen Glucose Metabolic Process Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Dihydrolipoyllysine-residue Acetyltransferase Activity Monosaccharide Metabolic Process Amide Biosynthetic Process Hexose Metabolic Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Pyruvate Dehydrogenase (acetyl-transferring) Activity Receptor Complex Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Early Endosome Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle
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