PAF1 and KAT8

Number of citations of the paper that reports this interaction (PMID 24837678)
0

Data Source:
BioGRID (pull down)

		PAF1	KAT8
Gene Name		Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	K(lysine) acetyltransferase 8
Image
Gene Ontology Annotations	Cellular Component	Cdc73/Paf1 Complex	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex
	Molecular Function	RNA Polymerase II Core Binding Chromatin Binding Protein Binding	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: FXR2 HIST1H1C HIST1H3A KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 TCEA1	11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53
Entrez ID		54623	84148
HPRD ID		10140	11381
Ensembl ID		ENSG00000006712	ENSG00000103510
Uniprot IDs		M0QX35 Q8N7H5	Q9H7Z6
PDB IDs		4M6T	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC
Enriched GO Terms of Interacting Partners?		Histone H4-K16 Acetylation Chromatin Organization Histone H4 Acetylation Chromosome Organization Histone Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Chromatin Modification Peptidyl-lysine Modification Organelle Organization Histone H2B Ubiquitination Histone Monoubiquitination Peptidyl-amino Acid Modification Regulation Of Gene Expression Histone Ubiquitination Positive Regulation Of Histone Methylation Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Cellular Protein Modification Process Regulation Of RNA Metabolic Process DNA Methylation Transcription, DNA-templated Positive Regulation Of Cellular Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression RNA Biosynthetic Process Positive Regulation Of Histone Modification Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process DNA Modification Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Protein Metabolic Process Nucleosome Assembly Regulation Of Histone Modification Chromatin Assembly Nucleosome Organization Regulation Of Metabolic Process Regulation Of Response To Drug	Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging
Tagcloud ?		ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails
Tagcloud (Difference) ?		ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma	acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails
Tagcloud (Intersection) ?